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Airway Mucus in Invasively Ventilated Critically Ill Patients

Stilma, Willemke (Faculteit Gezondheid); Lilien, Thijs A; Bos, Lieuwe DJ; Saatpoor, Aryen; Elsayed, Omar; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J; Bem, Reinout A; Linssen, Rosalie SN

Patients who are critically ill and receiving invasivemechanical ventilation are at increased risk for accumula-tion of secretions in the lower airways. Such accumula-tion of airway mucus can induce atelectasis and contributeto ventilator-associated pneumonia. Preventive airwaycare interventions, including …

2023-09-01AlgemeenArtikel

Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19—Insights from PRoVENT-COVID

Tripipitsiriwat, Athiwat; Suppapueng, Orawan; van Meenen, David M. P.; Paulus, Frederique (Lectoraat Critical Care); Hollmann, Markus W.; Sivakorn, Chaisith; Schultz, Marcus J.

Chronic obstructive pulmonary disease (COPD) is a risk factor for death in patients admitted to intensive care units (ICUs) for respiratory support. Previous reports suggested higher mortality in COPD patients with COVID-19. It is yet unknown whether patients with COPD were treated differently compared …

2023-09AlgemeenArtikel

Lung Ultrasound to Determine the Effect of Lower vs. Higher PEEP on Lung Aeration in Patients without ARDS—A Substudy of a Randomized Clinical Trial

Zimatore, Claudio; Algera, Anna Geke; Botta, Michela; Pierrakos, Charalampos; Serpa Neto, Ary; Grasso, Salvatore; Schultz, Marcus J.; Pisani, Luigi; Paulus, Frederique (Lectoraat Critical Care)

Background: Ventilation with lower positive end–expiratory pressure (PEEP) may cause loss of lung aeration in critically ill invasively ventilated patients. This study investigated whether a systematic lung ultrasound (LUS) scoring system can detect such changes in lung aeration in a study comparing …

2023-06AlgemeenArtikel

Incidence of Air Leaks in Critically Ill Patients with Acute Hypoxemic Respiratory Failure Due to COVID-19

Goossen, Robin L.; Verboom, Mariëlle; Blacha, Mariëlle; Smesseim, Illaa; Beenen, Ludo F. M.; van Meenen, David M. P.; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.

Subcutaneous emphysema, pneumothorax and pneumomediastinum are well-known complications of invasive ventilation in patients with acute hypoxemic respiratory failure. We determined the incidences of air leaks that were visible on available chest images in a cohort of critically ill patients with acute …

2023-03AlgemeenArtikel

Effect of mechanical power on mortality in invasively ventilated ICU patients without the acute respiratory distress syndrome

van Meenen, David M.P.; Algera, Anna Geke; Schuijt, Michiel T.U.; Simonis, Fabienne D.; van der Hoeven, Sophia M.; Neto, Ary Serpa; Abreu, Marcelo Gama de; Pelosi, Paolo; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.

BACKGROUND The mechanical power of ventilation (MP) has an association with outcome in invasively ventilated patients with the acute respiratory distress syndrome (ARDS). Whether a similar association exists in invasively ventilated patients without ARDS is less certain. OBJECTIVE To investigate the …

2023-01AlgemeenArtikel

The impact of high versus standard enteral protein provision on functional recovery following intensive care admission (PRECISE trial)

van Gassel, Rob J. J.; Bels, Julia L. M.; Tartaglia, Katrien; van Bussel, Bas C. T.; van Kuijk, Sander M. J.; Deane, Adam M.; Puthucheary, Zudin; Weijs, Peter J. M. (Lectoraat Voeding En Beweging); Vloet, Lilian; Beishuizen, Bert; De Bie Dekker, Ashley; Fraipont, Vincent; Lamote, Stoffel; Ledoux, Didier; Scheeren, Clarissa; De Waele, Elisabeth; van Zanten, Arthur R. H.; Mesotten, Dieter; van de Poll, Marcel C. G.

Background Critically ill patients are subject to severe skeletal muscle wasting during intensive care unit (ICU) stay, resulting in impaired short- and long-term functional outcomes and health-related quality of life. Increased protein provision may improve functional outcomes in ICU patients by attenuating …

2023AlgemeenArtikel

Effect of lung ultrasound-guided fluid deresuscitation on duration of ventilation in intensive care unit patients (CONFIDENCE)

Blok, Siebe G.; Mousa, Amne; Brouwer, Michelle G.; de Grooth, Harm-Jan; Neto, Ary Serpa; Blans, Michiel J.; den Boer, Sylvia; Dormans, Tom; Endeman, Henrik; Roeleveld, Timo; Scholten, Harm; van Slobbe-Bijlsma, Eline R.; Scholten, Erik; Touw, Hugo; van der Ven, Fleur Stefanie L. I. M.; Wils, Evert-Jan; van Westerloo, David J.; Heunks, Leo M. A.; Schultz, Marcus J.; Paulus, Frederique (Lectoraat Critical Care); Tuinman, Pieter R.

Background Fluid therapy is a common intervention in critically ill patients. It is increasingly recognised that deresuscitation is an essential part of fluid therapy and delayed deresuscitation is associated with longer invasive ventilation and length of intensive care unit (ICU) stay. However, optimal …

2023AlgemeenArtikel

Course of recovery of respiratory muscle strength and its associations with exercise capacity and handgrip strength: A prospective cohort study among survivors of critical illness

Major, Mel (Centre Of Expertise Urban Vitality); van Egmond, Maarten (Lectoraat Fysiotherapie - Transitie Van Zorg Bij Complexe Patiënten); Dettling-Ihnenfeldt, Daniela; Ramaekers, Stephan (Lectoraat Fysiotherapie - Transitie Van Zorg Bij Complexe Patiënten); Engelbert, Raoul (Centre Of Expertise Urban Vitality); van der Schaaf, Marike (Lectoraat Revalidatie In De Acute Zorg)

Background Mechanical ventilation affects the respiratory muscles, but little is known about long-term recovery of respiratory muscle weakness (RMW) and potential associations with physical functioning in survivors of critical illness. The aim of this study was to investigate the course of recovery of …

2023AlgemeenArtikel

Practice of Awake Prone Positioning in Critically Ill COVID-19 Patients-Insights from the PRoAcT-COVID Study

We describe the incidence, practice and associations with outcomes of awake prone positioning in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) in a national multicenter observational cohort study performed in 16 intensive care units in the Netherlands (PRoAcT−COVID-study). …

2022-11-26AlgemeenArtikel

Practice of Awake Prone Positioning in Critically Ill COVID–19 Patients––insights from the PRoAcT–COVID study

Stilma, W. (Faculteit Gezondheid); Valk, C.; Van Meenen, D.; Schultz, M.; Paulus, F. (Lectoraat Critical Care)

Introduction It is unknown how awake prone positioning was practiced in patients with COVID–19 in the second wave of the national outbreak in the Netherlands. Objectives We studied the practice of awake prone positioning in COVID–19 patients admitted to the ICU because of acute hypoxemic respiratory …

2022-10-24AlgemeenConferentiebijdrage

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