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Effectiviteit in stadiëring van prostaatcarcinomen: Ga68-PSMA vs. F18-Choline

Celine Dijkstra (Student); Desirée Uildriks (Student); Janine Baër (Begeleider); Ruurd Visser (Begeleider)

Voor de stadiëring van een prostaatcarcinoom wordt gebruik gemaakt van beeldvormend onderzoek, waaronder nucleair geneeskundig onderzoek als PET/CT of een whole body skeletscintigrafie. Doel van het onderzoek is het maken van een inschatting welke techniek (Ga68-PSMA PET/CT of F18-Choline PET/CT) effectiever …

2018-12-31GezondheidBachelor

ss-TEA

umc, radboud; Fleuren, Wilco W M; Verhoeven, Stefan; van den Beld, Sven; Alkema, Wynand (Data Science For Life Science & Health); de Vlieg, Jacob; Klomp, Jan P G

Background: G-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM) domain. Because of their structural and sequence conservation, the TM domains are often used in bioinformatics …

2011-08-10AlgemeenArtikel

Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

Duiker, E.; van der Heij-Meijer, Annemieke; van der Bilt, A. R. M.; Meersma, G.J.; Kooi, N.; van der Zee, A.G.J.; de Vries, E.G.E.; de Jong, Steven

Background: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. Methods: We investigated whether acquired cisplatin resistance affects sensitivity to recombinant …

2011-04-01AlgemeenArtikel

Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer

Pennarun, Bodvaël; van der Heij-Meijer, Annemieke; de Vries, Elisabeth G.E.; Kleibeuker, Jan H.; Kruyt, Frank; de Jong, Steven

Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to its two pro-apoptotic receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2. Primary components of the DISC are trimerized …

2010-04-01AlgemeenAndersoortig materiaal

Saturation mutagenesis reveals the importance of residues alphaR145 and alphaF146 of penicillin acylase in the synthesis of beta-lactam antibiotics

Jager, Simon A W; Shapovalova, Irina V; Jekel, Peter A; Alkema, Wynand B L (Data Science For Life Science & Health); Svedas, Vytas K; Janssen, Dick B

Penicillin acylase (PA) from Escherichia coli can catalyze the coupling of an acyl group to penicillin- and cephalosporin-derived beta-lactam nuclei, a conversion that can be used for the industrial synthesis of beta-lactam antibiotics. The modest synthetic properties of the wild-type enzyme make it …

2008-01-01AlgemeenArtikel

Unexpected enhancement of enantioselectivity in copper(II) catalyzed conjugate addition of diethylzinc to cyclic enones with novel TADDOL phosphorus amidite ligands

Keller, Erik (Biorefinery); Maurer, Jochen; Naasz, Robert; Schader, Thomas; Meetsma, Auke; Feringa, Ben L.

The copper(II) catalyzed enantioselective 1,4-addition reactions of diethylzinc to cyclic enones in the presence of novel phosphorus amidite ligands, easily prepared from α,α,α',α'-tetraphenyl-2,2'-dimethyl-1,3- dioxolane-4,5-dimethanol (TADDOL) derivatives, resulted in e.e.s up to 71% for cyclohexenone …

1998-07-17AlgemeenArtikel

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