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Study of the direct interaction of caveolin 1 and cPLA2α

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Study of the direct interaction of caveolin 1 and cPLA2α

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Samenvatting

Between endothelial cells, tight- and adherens junctions are maintained to act as a barrier. This barrier function is vital for the state of the bloodvessel, if it is damaged, an immuneresponse can be triggered and give rise to artherosclerosis. This eventually would block the blood flow. It is found that cPLA2α plays a role in maintaining those tight- and adherens junctions. cPLA2α is a cytosolic protein that plays a major role in the immunerespons. It translocalises to the golgi upon confluency in human umbilical vein endothelial cells (HUVEC), while it was thought that it was dependant on calcium stimulation to translocalise to a membrane. Caveolin 1 is thought to recruit cPLA2α at the golgi and maintaining it there. It seems that this goes via a direct interaction. Attempts to prove the direct interaction of caveolin 1 and cPLA2α via an in vitro binding assay have been done and described here, but did not were succesfull up to this date. Why these attempts weren´t succesfull is discussed, as well as possible solutions to the problems stated.

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OrganisatieHogeschool Utrecht
OpleidingBiologie en Medisch Laboratorium Onderzoek
AfdelingLife Sciences en Chemistry
PartnersUtrecht University
Jaar2007
TypeBachelor
TaalEngels

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