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Effects of induction of labour versus expectant management in women with impending post-term pregnancies

Rechten:

Effects of induction of labour versus expectant management in women with impending post-term pregnancies

Rechten:

Samenvatting

Background:
Post-term pregnancy, a pregnancy exceeding 294 days or 42 completed weeks, is associated with
increased perinatal morbidity and mortality and is considered a high-risk condition which requires specialist surveillance
and induction of labour. However, there is uncertainty on the policy concerning the timing of induction for post-term
pregnancy or impending post-term pregnancy, leading to practice variation between caregivers. Previous studies on
induction at or beyond 41 weeks versus expectant management showed different results on perinatal outcome though
conclusions in meta-analyses show a preference for induction at 41 weeks. However, interpretation of the results is
hampered by the limited sample size of most trials and the heterogeneity in design. Most control groups had a policy
of awaiting spontaneous onset of labour that went far beyond 42 weeks, which does not reflect usual care in The
Netherlands where induction of labour at 42 weeks is the regular policy. Thus leaving the question unanswered if
induction at 41 weeks results in better perinatal outcomes than expectant management until 42 weeks.

Methods/design:
In this study we compare a policy of labour induction at 41 + 0/+1 weeks with a policy of expectant
management until 42 weeks in obstetrical low risk women without contra-indications for expectant management until
42 weeks and a singleton pregnancy in cephalic position. We will perform a multicenter randomised controlled clinical
trial. Our primary outcome will be a composite outcome of perinatal mortality and neonatal morbidity. Secondary
outcomes will be maternal outcomes as mode of delivery (operative vaginal delivery and Caesarean section), need for
analgesia and postpartum haemorrhage (≥1000 ml). Maternal preferences, satisfaction, wellbeing, pain and anxiety will
be assessed alongside the trial.

Discussion:
his study will provide evidence for the management of pregnant women reaching a gestational age of
41 weeks.

Toon meer
OrganisatieZuyd Hogeschool
Opleiding
Instituut
LectoraatLectoraat Midwifery Science
Gepubliceerd inBMC Pregnancy and Childbirth BioMed Central, Vol. 2014
Jaar2014
TypeArtikel
ISSN1471-2393
TaalEngels

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