Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data …

Ubiquitin (Ub) is a protein which post-translationally modifies other proteins (its target substrates) and determines their cellular fate. Ub can label substrates for degradation, it can also alter the location of their substrates within a cell or even affect their activity. Chains can be formed via …

Deze afstudeeropdracht over de impact van eiwit uit sprinkhanen versus dierlijk eiwit is tot stand gekomen m.b.v. interviews en literatuurstudie. De hoofdvraag is als volgt beschreven: Welke impact heeft de wijziging van het gebruik van sprinkhaneneiwit t.o.v. het gebruik van eiwit uit de melkveehouderijsector? …

Klotho knock-out mice are an important model for vascular calcification, which is associated with chronic kidney disease. In chronic kidney disease, serum magnesium inversely correlates with vascular calcification. Here we determine the effects of serum magnesium on aortic calcification in Klotho knock-out …

De opmars van zuivelvervangers is onmiskenbaar. En de groei versnelt, zo valt op te maken uit marktonderzoek. Hoe gaan zuivelverwerkers om met de transitie van dierlijk naar plantaardig eiwit? En wat is het perspectief voor de melkveehouder?

In recent years the dairy industry had to face new environmental regulations and consumption evolutions. The soybean meal utilization as a protein source is not adapted to the GMO-free milk production. That’s why there was a growing interest for GMO-free rapeseed meal to replace soybean meal but since …

Background & aims: A low muscle mass before start of treatment and loss of muscle mass during chemotherapy is related to adverse outcomes in patients with cancer. In this randomized controlled trial, the effect of nutritional counseling on change in muscle mass and treatment outcome in patients with …

Background Malnutrition is common in patients with Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI) and is associated with institutionalization and increased mortality. Malnutrition is the result of a negative energy balance, which could be due to reduced dietary intake and/or higher …

Background: The Global Leadership Initiative on Malnutrition (GLIM) created a consensus-based framework consisting of phenotypic and etiologic criteria to record the occurrence of malnutrition in adults. This is a minimum set of practicable indicators for use in characterizing a patient/client as malnourished, …

Background: Over the last decade, different screening tools for malnutrition have been developed. Within these tools, a distinction can be made between tools that assess nutritional risk and tools that assess protein energy malnutrition. Insights in differences in characteristics of participants at risk …