OBJECTIVE: Juvenile dermatomyositis (DM) is an inflammatory myopathy in which the immune system targets the microvasculature of the skeletal muscle and skin, leading to significant muscle weakness and exercise intolerance, although the precise etiology is unknown. The goal of this study was to investigate …

Penicillin acylase (PA) from Escherichia coli can catalyze the coupling of an acyl group to penicillin- and cephalosporin-derived beta-lactam nuclei, a conversion that can be used for the industrial synthesis of beta-lactam antibiotics. The modest synthetic properties of the wild-type enzyme make it …

This thesis is an overview of the market and management for WEEE (waste of electrical and electronic equipment) in Bulgaria. It was executed to answer certain questions to WEEE Forum, which was my internship provider. Chapter 2 analyzes the WEEE market and business developments in Bulgaria. Chapter 2.1 …

Small scale producers face many opportunities and also huge challenges in today’s markets. Market liberalization since the 1980s has cut back the support services provided by the state and forced producer to face the risks of often weak and volatile markets. Further more those who are able to access …

Colgate-Palmolive is an American company which operates on international level with the production and selling of oral, personal and home care products and pet nutrition products with a good price-quality relation. The organisation has set up a sales and marketing organisation in Spain in order to launch …

From June 28 to July 7 the National Arts Festival took place in Grahamstown, South Africa. For the 20th time Cue, a daily print newspaper about the Festival, was produced by Rhodes University journalism students. It was the first time that the newspaper was printed in full color. Cue is at the core …

Genomics has multiplied the number of targets for new therapeutic interventions, but this has not yet lead to a marked increase of pharma pipeline outputs. The complexity of protein function in higher order biological systems is often underestimated. Translation from in vitro and in vivo results to the …

Bisphosphonates (BPs) are widely used in the treatment of osteolytic bone disease associated with multiple myeloma, and have been demonstrated to exert antitumor effects both in vitro and in vivo. However, the precise molecular mechanisms involved in the direct antitumor effects of BPs in vitro are not …

Achtergrond en probleemstelling In dit rapport wordt een onderzoek naar energiezorg binnen zes locaties van Stichting Saffier beschreven. Stichting Saffier is een christelijke zorgorganisatie voor ouderen in Den Haag. Wegens mogelijke kostenreductie en de wens te voldoen aan wettelijke verplichtingen …

Binnen het projectonderwijs wordt nog vaak drooggezwommen. Enerzijds door de verstrekte projectopdrachten anderzijds door de suboptimalisatie van oplossingen. Deze zijn namelijk sterk afhankelijk van de verbonden modules en docenten. In de praktijk zijn de oplossingen echter altijd een afweging van …