Background Hereditary spastic paraplegia (HSP) is a group of inherited disorders characterized by progressive spastic paresis of the lower limbs. Treatment is often focused on reducing spasticity and its physical consequences. To better address individual patients' needs, we investigated a broad range …

ABSTRACT: Introduction: The literature shows that Korsakoff’s syndrome is associated with a wide range of severe comorbid somatic and psychiatric health problems that lead to care needs in several domains of functioning. Aim: To provide a comprehensive overview of Korsakoff patients’ health conditions …

Abstract Background An increasing number of the ageing population worldwide is at risk of becoming frail and incapacitated. This has the potential to impact not only on the well-being of individuals but also on the sustainability of healthcare systems. Objective The aim of this study was to explore …

AIM: Early intervention programs for first-episode psychosis have led to the awareness that the period before onset of a first episode is important in light of early intervention. This has induced a focus on the so-called 'at risk mental state' (ARMS). Individuals with ARMS are at increased risk for …

Increasing awareness of the impact of frailty on elderly people resulted in research focusing on factors that contribute to the development and persistence of frailty including nutrition and physical activity. Most effort so far has been spent on understanding the association between protein intake and …

Paul Wagstaff Commemorative Lecture 2019Prof. dr. Hans HobbelenHanze University of Applied Sciences Groningen, the NetherlandsPhysiotherapy and FrailtyFor a physiotherapist it can be difficult to use the term frailty in relation to the physical condition of a patient. We should focus on improvement of …

Frailty is a disputed but important concept in the care of older people. The agreed definition ( Fried et al 2001) is clinically driven and focusses on physical components and incapacity. But frailty is determined not only by disability and comorbidity. How do those defined by others as frail – perceive …

Background: Optimal self-management in kidney transplant recipients is essential for patient and graft survival, reducing comorbidity and health care costs while improving the quality of life. However, there are few effective interventions aimed at providing self-management support after kidney transplantation. Objective: …

OBJECTIVES: To determine the risk of first unplanned all-cause readmission and mortality of patients ≥70 years with acute myocardial infarction (AMI) or heart failure (HF) and to explore which effects of baseline risk factors vary over time. METHODS: A retrospective cohort study was performed on hospital …

In children developmental disorders expresses themselves by a variable presentation of symptoms and frequent manifestation of comorbidity of a complex nature. In addition to the classification of a disorder, individualising diagnostics is a means to realize assessment and treatment that are fine-tuned …