This thesis provides a report on research aimed at enhancing treatment of patients with bipolar disorder. We describe various aspects of treatment of bipolar disorder. The central study reported in this thesis is an effect study of a multicomponent intervention, Collaborative Care. Chapter 1 describes …

Consensus on red flags and terminology of atypical speech and language development Objectives Atypical speech and language development is one of the most common developmental problems in young children. However, consensus lacks on clinical signs and on diagnostic terminology. The aim of our study is …

BACKGROUND: Current evidence shows that manual therapy elicits analgesic effect in different populations (healthy, pain inflicted and patients with musculoskeletal pain) when carried out at the spinal column, although the clinical significance of these effects remains unclear. Also the analgesic effects …

One of the issues concerning the replacement of natural gas by green gas is the seasonal pattern of the gas demand. When constant production is assumed, this may limit the injected quantity of green gas into a gas grid to the level of the minimum gas demand in summer. A procedure was proposed to increase …

Energy efficiency, greenhouse gas reduction and cost price of a green gas supply chain were evaluated. This supply chain is based on co-digestion of dairy cattle manure and maize, biogas upgrading and injection into a distribution gas grid. A defined reference scenario reflects the current state of practice, …

This study investigates the clinical course of and prognostic factors for quality of life (Short Form 36 items Health survey (SF-36)) and global perceived effect (GPE) in patients treated for chronic nonspecific low back pain at 5 and 12-months follow-up. Data from a prospective cohort (n ¼ 1760) of …

BACKGROUND: Given the negative consequences of early alcohol use for health and social functioning, it is essential to detect children at risk of early drinking. The aim of this study is to determine predictors of early alcohol use that can easily be detected in Preventive Child Healthcare (PCH). METHODS: …

To develop a self-management program with an additional eHealth module, using the six steps of the intervention mapping (IM) protocol, to help employees with complaints of the arm, neck, and/or shoulder (CANS) cope with their problems. In Step 1 of the IM protocol, a needs assessment was performed consisting …

Anterior cruciate ligament (ACL) injury prevention programs have been successful in the short term. Motor learning strategies with an internal focus (IF) to body movements have traditionally been utilized, but may be less suitable than an external focus (EF) for the acquisition and control of complex …

Objectives: Participation is considerably restricted in children and adolescents with acquired brain injury (ABI) as compared to their healthy peers. This systematic review aims to identify which factors are associated with participation in children and adolescents with ABI. Methods: A systematic search …