Kwetsbaarheid wordt gekenmerkt door verminderd fysiek functioneren en wordt bij voorkeur in een vroeg stadium gediagnosticeerd (bijvoorbeeld tijdens pre-kwetsbaarheid). Helaas ontbreken gevoelige tools die kunnen helpen bij vroege opsporing. Op bloed gebaseerde biomarkers zouden uitstekende hulpmiddelen …

Om inzicht te krijgen in spierveroudering is genexpressie gemeten in vastus lateralis biopten van jonge en oude mannen en vrouwen. We vonden dat tijdens het ouder worden bij beide geslachten dezelfde categorieën genen in spieren worden aan- en uitgeschakeld (“gereguleerd”); de mate van deze zogenaamde …

Lichamelijke zwakte is een belangrijk onderdeel van kwetsbaarheid en komt veel voor bij oudere volwassenen. Terwijl vrouwen een hogere prevalentie en een eerder begin van kwetsbaarheid kennen zijn sekseverschillen in de ontwikkeling van lichamelijke zwakte nauwelijks bestudeerd. Daarom hebben we in spieren …

Protein acylation via metabolic acyl-CoA intermediates provides a link between cellular metabolism and protein functionality. A process in which acetyl-CoA and acetylation are fine-tuned is during myogenic differentiation. However, the roles of other protein acylations remain unknown. Protein propionylation …

Field of study decisions are important for children’s future life chances, as significant differences exist in terms of financial and status benefits across fields of study. We examine whether the economic or the cultural status of the parents is more influential in shaping their children’s expectations …

We tested the hypothesis that in human ageing a decreased intramuscular acylcarnitine status is associated with (pre-)frailty, reduced physical performance and altered mitochondrial function. Results showed that intramuscular total carnitine levels and acetylcarnitine levels were lower in (pre-)frail …

This study tested the hypothesis that in human aging, a decreased intramuscular acylcarnitine status is associated with (pre-)frailty, reduced physical performance, and altered mitochondrial function. We used a cross-sectional study design with well-matched fit and (pre-)frail old males and females, …

In recent studies on the association between education and fertility, increased attention has been paid to the field of study. Women who studied in traditionally more “feminine” fields, like care, teaching, and health, were found to have their children earlier and to have more children than other women. …

Carnitine/choline acyltransferases play diverse roles in energy metabolism and neuronal signalling. Our knowledge of their evolutionary relationships, important for functional understanding, is incomplete. Therefore, we aimed to determine the evolutionary relationships of these eukaryotic transferases. …