The NANOSPRESSO project is a pioneering response to the complex challenge of treating orphan diseases, which, despite affecting millions of people globally, have only scant therapeutic options. This initiative represents a paradigm shift by decentralizing the production of personalized nucleic acid nanomedicines. Integrating …

This research has proved that the implementation of a Modular Connection System (MCS1) for the “WET CELL” project is not only possible but also promising, as it successfully demonstrates how modularity, circularity, and material reusability can be achieved through the optimal design and material selection. …

Brain disorders, such as Alzheimer’s disease and epilepsy have been linked to an imbalance in excitatory and inhibitory (E/I) inputs in the brain. However, the molecular mechanisms underlying E/I balance and plasticity in the brain are largely unresolved. Inhibitory synapses have a strong impact on brain …

Introduction The Dutch Medical Doctor-Global Health (MD-GH) prepares to work in low-resource settings (LRS) by completing a hybrid postgraduate training program of 2 years and 9 months, with clinical and public health exposure in the Netherlands and a Global Health residency in LRS. The objectives of …

Municipalities collaborate with citizens to find locally adapted ways to deal with the energy transition. Industry clusters work together with regional governments and knowledge institutions to develop and test new sustainable materials. Universities co-create with students and industry to find a more …

The project for a mixed housing complex in the Taxandria zone in Waalwijk promotes a locally based development, inspired by the urban grain of the old city center. A variety of block types and terraced housing with experimental tiny and medium scale living units is arranged along covered alleyways and …

Construction and Demolition Waste (CDW) is the main driver of resource consumption and waste generation in Europe. Although most European countries achieved 70% recovery rate of CDW, the majority is used for backfilling. Therefore, opportunities for Circular Economy (CE) practices in CDW management are …

The Self-Production Economy as a trend is based on the availability and accessibility of digital design and manufacturing technology to a wide range of individuals. Such technology allows them to create their own products with the quality and functionality that, so far, only industrial manufacturers …

Objectives Decision-making for patients with a locally advanced laryngeal carcinoma (T3 and T4) is challenging due to the treatment choice between organ preservation and laryngectomy, both with different and high impact on function and quality of life (QoL). The complexity of these treatment decisions …

The contemporary use of resources in the ‘take-make-waste’ economy accounts for 70% of global greenhouse gas emissions, demonstrating unsustainable patterns of consumption and production. Therefore, the status quo of business operations needs to be changed. This study aims to find out how a circular …