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Multilayered Tissue Assemblies Through Tuneable Biodegradable Polyhydroxyalkanoate Polymer (Mesh)-Reinforced Organ-Derived Extracellular Matrix Hydrogels

Getova, Vasilena E.; Pascual, Alex; Dijkstra, Rene; Gładysz, Magdalena Z.; Ubels, Didi; Wlodarczyk-Biegun, Malgorzata K.; Burgess, Janette K.; Siebring, Jeroen (Bioconversion And Fermentation Technology); Harmsen, Martin C.

Multi-layer cell constructs produced in vitro are an innovative treatment option to support the growing demand for therapy in regenerative medicine. Our research introduces a novel construct integrating organ-derived decellularised extracellular matrix (dECM) hydrogels and 3D-printed biodegradable polymer …

2025-07-11Techniek; …Artikel

Melt Electrowriting of Polyhydroxyalkanoates for Enzymatically Degradable Scaffolds

Gładysz, Magdalena Z.; Ubels, Didi; Koch, Marcus; Amirsadeghi, Armin; Alleblas, Frederique; Kamperman, Marleen; Siebring, Jeroen; Nagelkerke, Anika; Włodarczyk-Biegun, Małgorzata K.; van Vliet, Sander

Melt electrowriting (MEW) enables precise scaffold fabrication for biomedical applications. With a limited number of processable materials with short and tunable degradation times, polyhydroxyalkanoates (PHAs) present an interesting option. Here, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and …

2024-11-12AlgemeenArtikel

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Multilayered Tissue Assemblies Through Tuneable Biodegradable Polyhydroxyalkanoate Polymer (Mesh)-Reinforced Organ-Derived Extracellular Matrix Hydrogels

Melt Electrowriting of Polyhydroxyalkanoates for Enzymatically Degradable Scaffolds

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