Hyperhomocysteinemia is a risk factor for cardiovascular disease, neurological disorders, and bone abnormalities. The key enzyme in homocysteine metabolism, cystathionine-β-synthase (CBS) is recognized as a target for new homocysteine-lowering therapies including enzyme replacement and gene therapy. …

Dit onderzoek gaat over leiderschap in zorgorganisaties die werken met zelforganiserende teams. Het is uitgevoerd binnen een organisatie die zorg biedt aan mensen met een verstandelijke en/of lichamelijke beperking. De organisatie wilde haar zorg vernieuwen: cliënten moesten meer regie krijgen over hun …

Light profoundly impacts many aspects of human physiology and behaviour, including the synchronization of the circadian clock, the production of melatonin, and cognition. These effects of light, termed the non-visual effects of light, have been primarily investigated in laboratory settings, where light …

This paper explores country-level macro-structural conditions that are associated with social capital, measured as individuals’ access to social resources. To explain differences in social capital across societies, we formulate hypotheses based on welfare state generosity, cultural orientations (collectivism …

In recent years, the debate about the design of the monetary system has become increasingly prevalent. A major topic within this debate is central bank digital currency or CBDC for short. A survey by the Bank of International Settlements (BIS) shows that in 2022, nine in ten central banks (CB) explored …

Estimating the remaining useful life (RUL) of an asset lies at the heart of prognostics and health management (PHM) of many operations-critical industries such as aviation. Mod- ern methods of RUL estimation adopt techniques from deep learning (DL). However, most of these contemporary tech- niques deliver …

Although much research has been done into the importance of IT Capabilities (ITC), Digital Leadership (DL) and Digital Transformation (DT) with regard to organizations’ firm performance and ability to thrive in the current digital market, there is little research on qualifying which specific ITC and …

Het doel van dit onderzoek was om vanuit een individuele 6 weken non-lineaire non- trainingsmethode gericht op attractoren een verschil in de kwaliteit van bewegen bepaald kon worden die berust op een wendbaarheid attractorsanalyse bij het CTO Talent group <18 Baseball & Softball Amsterdam. Daarnaast …

De Colombiaanse Nobelprijswinnaar Gabriel García Márquez (1927-2014) was niet alleen een begenadigd romancier – denk aan Honderd jaar eenzaamheid, Kroniek van een aangekondigde dood en Liefde in tijden van cholera – hij was in Latijns-Amerika ook bekend als journalist.

The aeronautical industry is expanding after a period of economic turmoil. For this reason, a growing number of airports are facing capacity problems that can sometimes only be resolved by expanding infrastructure, with the inherent risks that such decisions create. In order to deal with uncertainty …