Objectives: A large portion of anogenital cancers is caused by high-risk human papillomavirus (hrHPV) infections, which are especially common in HIV-infected men. We aimed to compare the incidence and clearance of anal and penile hrHPV infection between HIV-infected and HIV-negative MSM. Design: Analyses …

DNA-based techniques are frequently used to confirm the relatedness of putative outbreak isolates. These techniques often lack the discriminatory power when analyzing closely related microbes such as E. coli. Here the value of Raman spectroscopy as a typing tool for E. coli in a clinical setting was …

The fungal species Trichoderma harzianum is widely used as a biological agent in crop protection. To verify the continued presence of this fungus on plant roots manually inoculated with T. harzianum strain T22, a Q-PCR was designed using specific probes for this particular strain. To develop these molecular …

Mobile Rapid-DNA devices have recently become available on the market. These devices can perform DNA analyses within 90 min with an easy ‘sample in–answer out’ system, with the option of performing comparisons with a DNA database or reference profile. However, these fast mobile systems cannot yet compete …

Purpose: Parentally transmitted germ-line chromothripsis (G-CTH) has been identified in only a few cases. Most of these rearrangements were stably transmitted, in an unbalanced form, from a healthy mother to her child with congenital abnormalities probably caused by de novo copy-number changes of dosage …

Motivation: Unambiguous sequence variant descriptions are important in reporting the outcome of clinical diagnostic DNA tests. The standard nomenclature of the Human Genome Variation Society (HGVS) describes the observed variant sequence relative to a given reference sequence. We propose an efficient …

In het kader van de Kaderrichtlijn Water (KRW) vormt monitoring een zware belasting voor de jaarlijkse begroting van waterbeheerders. Een goedkopere monitoringsmethode is daarom gewenst. Environmental DNA (eDNA) is in potentie geschikt om de huidige monitoring te vervangen. De verwachting is dat het …

Gebiedsmarketing en de rol van de ondernemer. Marketing is verbinding merk en stakeholders, met o.a. productverbetering, communicatie vanuit het DNA!