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Dutch translation and validation of the Communicative Participation Item Bank (CPIB)—short form

van Sluis, Klaske E.; Passchier, Ellen; van Son, Rob J. J. H.; van der Molen, Lisette; Stuiver, Martijn (Lectoraat Functioneel Herstel Bij Kanker); van den Brekel, Michiel W. M.; Van den Steen, Leen; Kalf, Johanna G.; van Nuffelen, Gwen

Background Several conditions and diseases can result in speech problems that can have a negative impact on everyday functioning, referred to as communicative participation. Subjective problems with acquired speech problems are often assessed with the speech handicap index (SHI). To assess generic participation …

2023-01AlgemeenArtikel

Comparison of genotyping and weight of evidence results when applying different genotyping strategies on samples from a DNA transfer experiment

Duijs, Francisca E.; Meijers, Erin; Kokshoorn, Bas (Lectoraat Forensisch Onderzoek); Sijen, Titia

In this study, we assessed to what extent data on the subject of TPPR (transfer, persistence, prevalence, recovery) that are obtained through an older STR typing kit can be used in an activity-level evaluation for a case profiled with a more modern STR kit. Newer kits generally hold more loci and may …

2023-01AlgemeenArtikel

Effect of mechanical power on mortality in invasively ventilated ICU patients without the acute respiratory distress syndrome

van Meenen, David M.P.; Algera, Anna Geke; Schuijt, Michiel T.U.; Simonis, Fabienne D.; van der Hoeven, Sophia M.; Neto, Ary Serpa; Abreu, Marcelo Gama de; Pelosi, Paolo; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.

BACKGROUND The mechanical power of ventilation (MP) has an association with outcome in invasively ventilated patients with the acute respiratory distress syndrome (ARDS). Whether a similar association exists in invasively ventilated patients without ARDS is less certain. OBJECTIVE To investigate the …

2023-01AlgemeenArtikel

Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19

Daenen, Katrijn; Huijben, Jilske A; Boyd, Anders; Bos, Lieuwe D J; Stoof, Sara C M; van Willigen, Hugo; Gommers, Diederik A M P J; Moeniralam, Hazra S; den Uil, Corstiaan A; Juffermans, Nicole P; Kant, Merijn; Valkenburg, Abraham J; Pillay, Janesh; van Meenen, David M P; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J; Dalm, Virgil A S H; van Gorp, Eric C M; Schinkel, Janke; Endeman, Henrik

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose …

2023-01AlgemeenArtikel

Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.

B. den Hollander; A.R.J. Veenvliet; Marieke Lindenschot; P. van Essen; G. Peters; A. Santos-Gómez; M. Olivella; X. Altafaj; M.M. Brands; B.A.W. Jacobs; C.D. van Karnebeek

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

2023AlgemeenArtikel

Physiotherapy with integrated virtual reality for patients with complex chronic low back pain: protocol for a pragmatic cluster randomized controlled trial (VARIETY study).

S. Slatman; R. Ostelo; H. van Goor; Bart Staal; J. Knoop

BACKGROUND: Chronic low back pain (CLBP) is the most common chronic pain condition worldwide. Currently, primary care physiotherapy is one of the main treatment options, but effects of this treatment are small. Virtual Reality (VR) could be an adjunct to physiotherapy care, due to its multimodal features. …

2023AlgemeenArtikel

Cartilage tissue turnover increases with high- compared to low-intensity resistance training in patients with knee OA

Thudium, Christian S.; Engstrøm, Amalie; Bay-Jensen, Anne Christine; Frederiksen, Peder; Jansen, Nuria; De Zwart, Arjan; van der Leeden, Marike; Dekker, Joost; Lems, Willem; Roorda, Leo; van Spil, Willem Evert; Van der Esch, Martin (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen)

Objectives To investigate cartilage tissue turnover in response to a supervised 12-week exercise-related joint loading training program followed by a 6-month period of unsupervised training in patients with knee osteoarthritis (OA). To study the difference in cartilage tissue turnover between high- and …

2023AlgemeenArtikel

Effect and process evaluation of a preschool-based intervention to promote an early childhood education and care teacher-parent partnership about healthy behaviours in children: Study protocol for the cluster randomised controlled trial CO-HEALTHY

Toussaint, Nicole (Urban Vitality); Streppel, Martinette T. (Lectoraat Voeding En Beweging); Mul, Sandra (Lectoraat Voeding En Beweging); Gündüz, Meryem (Lectoraat Voeding En Beweging); van Verseveld, Marloes D.A.; Janssen, Mirka (Lectoraat Bewegen In En Om School); Weijs, Peter J. M. (Lectoraat Voeding En Beweging); Fukkink, Ruben G. (Kenniscentrum Onderwijs En Opvoeding)

Background Early Childhood Education and Care (ECEC) teachers at urban preschools are potential key figures to promote healthy behaviours in disadvantaged young children and to engage parents in lifestyle-related topics. An ECEC teacher-parent partnership regarding healthy behaviours may support parents …

2023AlgemeenArtikel

Nocturnal Hemodialysis Leads to Improvement in Physical Performance in Comparison with Conventional Hemodialysis

Dam, Manouk; Weijs, Peter J. M. (Lectoraat Voeding En Beweging); van Ittersum, Frans J.; Hoekstra, Tiny; Douma, Caroline E.; van Jaarsveld, Brigit C.

End-stage kidney disease patients treated with conventional hemodialysis (CHD) are known to have impaired physical performance and protein-energy wasting (PEW). Nocturnal hemodialysis (NHD) was shown to improve clinical outcomes, but the evidence is limited on physical performance and PEW. We investigate …

2023AlgemeenArtikel

Patients with and without COVID-19 in the Intensive Care Unit: Physical Status Outcome Comparisons 3 Months after Discharge

Bas Cijs (Onderzoeker); Karin Valkenet (Onderzoeker); Germijn Heijnen (Onderzoeker); Anne Visser‑Meily (Onderzoeker); Marike van der Schaaf (Onderzoeker)

Objective: Many patients with COVID-19 infections were admitted to an intensive care unit (ICU). Physical impairments are common after ICU stays and are associated with clinical and patient characteristics. To date, it is unknown if physical functioning and health status are comparable between patients …

2023GezondheidArtikel

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