Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

In its past, terrorism has evolved from old terrorism into new, even more catastrophic terrorism. Today, hundreds or even thousands of people can become victim from one moment to the other, through which the fear for terrorist attacks has increased a lot lately. Next to that, Europe has become much more …

In 2007, the Dutch Ministry of the Interior and Kingdom Relations initiated the program 'Veilige Publieke Taak'. It was designed to provide employers with guidelines and solutions for handling aggression and violence towards employees with a public task. One of the most important initiatives of this …

Energy management and carbon accounting schemes are increasingly being adopted as a corporate response to climate change. These schemes often demand the setting of ambitious targets for the reduction of corporate greenhouse gas emissions. There is however only limited empirical insight in the companies’ …

The aim of this research is to assess the potential impact of the CO2 Performance Ladder on CO2 emission reduction. The CO2 Performance Ladder is a new green procurement scheme that has been adopted by several public authorities in the Netherlands; it is a staged certification scheme for energy and CO2 …

In recent years, the transport industry has encountered numerous challenges. It experienced strong growth, but also many uncertainties. In many cases, logistics service providers were forced to change their strategy. So, the question for logistics service providers arises “how to deal best with uncertainties?” …

In this dissertation, the European Commission's selection process of policy instruments to tackle climate change has been reviewed, with the main focus on understanding what internal factors have influenced the Commission in this process and how this has led to the implementation of soft policy instruments. …

More and more local bottom-up energy initiatives are emerging. Those involved encounter many barriers during the realization of their ideas. As the generation of renewable energy is mostly included, these local initiatives contribute to the targets set at regional, national & EU level. At the same time, …

PURPOSE: The purpose of this study was to gain insight into how low back pain (LBP) patients conceptualize the construct of expectations regarding treatment. METHODS: This study was nested within a mixed-method randomized clinical trial comparing three primary care interventions for LBP. A total of 77 …

The implementation of the new mathematical knowledge base in Dutch teacher education institutes for primary education raises a need for curriculum development. Teacher educators have to raise student teachers’ subject matter knowledge to a higher level. In working on this aim teacher educators experience …