Background: Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of metabolic side-effects, e.g. insulin resistance, glucose intolerance and diabetes. …

Axon Digital Design develops modular systems and equipment for audio and video signal processing and monitoring, mainly aimed at the broadcasting industry. The recent successes of 3D film productions have pushed the consumer TV market into a new era: 3D television in the living room. One fundamental …

A common strategy to assign keywords to documents is to select the most appropriate words from the document text. One of the most important criteria for a word to be selected as keyword is its relevance for the text. The tf.idf score of a term is a widely used relevance measure. While easy to compute …

Phylogenetic patterns show the presence or absence of certain genes in a set of full genomes derived from different species. They can also be used to determine sets of genes that occur only in certain evolutionary branches. Previously, we presented a database named PhyloPat which allows the complete …

In The Guardian, Alan Rushbridger compared the future of newspapers to climate change. Five years ago, many climatologists were sceptical whether climate change was a real and serious issue. Today, most scientists agree that global warm ing is a fact of life. In the world of newspapers, at present, almost …

Introduction: To reduce continuously increasing costs in drug development, adverse effects of drugs need to be detected as early as possible in the process. In recent years, compound-induced gene expression profiling methodologies have been developed to assess compound toxicity, including Gene Ontology …

Several models in data analysis are estimated by minimizing the objective function defined as the residual sum of squares between the model and the data. A necessary and sufficient condition for the existence of a least squares estimator is that the objective function attains its infimum at a unique …

Estimation of the factor model by unweighted least squares (ULS) is distribution free, yields consistent estimates, and is computationally fast if the Minimum Residuals (MinRes) algorithm is employed. MinRes algorithms produce a converging sequence of monotonically decreasing ULS function values. Various …