Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character …

Background: All countries are affected by one or more forms of malnutrition. 90 Percent of chronically malnourished children in developing countries live in Africa and Asia. India accounts for more than three in ten stunted children worldwide. Recent evidence shows that one in four children in India …

Introduction: Neuromuscular disease is a progressive muscle disease, whereby patients suffer from a decrease in muscle mass. Although muscle diseases can hardly be cured, treatment is possible with adequate protein intake. However, there is no general nutritional guideline available for patients with …

Introduction: Neuromuscular diseases (NMD) are a heterogeneous group of acquired or inherited diseases affecting the peripheral nervous system and muscle mass. The consequences of NMD are loss of muscle mass, function, and posture. Loss of muscle mass causes weakness, a decrease in mobility and cardiac …

The world population is aging, which increases the prevalence of physical limitation and chronic diseases. A major cause of these physical limitation and chronic diseases is a low muscle mass (sarcopenia) and/or a high fat mass (obesity). Coexistence of sarcopenia and obesity, called sarcopenic obesity, …

Background & aims Plasma citrulline concentration is considered to be a marker for enterocyte metabolic mass and to reflect its reduction as may occur during intestinal dysfunction. Strenuous exercise can act as a stressor to induce small intestinal injury. Our previous studies suggest that this comprises …