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Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach

Jonas van Ertvelde (Onderzoeker); Anouk Verhoeven (Onderzoeker); Amy Maerten (Onderzoeker); Axelle Cooreman (Onderzoeker); Bruna dos Santos Rodrigues (Onderzoeker); Julen Sanz-Serrano (Onderzoeker); Milos Mihajlovic (Onderzoeker); Ignacio Tripodi (Onderzoeker); Marc Teunis (Onderzoeker); Ramiro Jover (Onderzoeker); Thomas Luechtefeld (Onderzoeker); Tamara Vanhaecke (Onderzoeker); Jian Jang (Onderzoeker); Mathieu Vinken (Onderzoeker)

Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected …

2023GezondheidArtikel

In vitro–in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans

Shi, M.; Dong, Y.; Bouwmeester, H.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present study presents an in vitro–in silico approach to predict the effect of inter-individual and inter-ethnic kinetic variations in the cardiotoxicity of R- …

2022-05-23GezondheidArtikel

New approach methodologies (NAMs) for human-relevant biokinetics predictions

Punt, A.; Bouwmeester, H.; Blaauboer, B.J.; Strikwold, M. (Lector)

For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion (ADME/biokinetics) in chemical risk evaluations are a bottleneck. To enhance the field, a team …

2020-06-08GezondheidArtikel

Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone

Shi, M.; Bouwmeester, H.; Rietjens, I.M.C.M.; Strikwold, M. (Associate Lector)

Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data …

2020-05-04GezondheidArtikel

Integrating physiologically based kinetic (PBK) and Monte Carlo modelling to predict inter-individual and inter-ethnic variation in bioactivation and liver toxicity of lasiocarpine

Ning, J.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

The aim of the present study was to predict the effect of inter-individual and inter-ethnic human kinetic variation on the sensitivity towards acute liver toxicity of lasiocarpine in the Chinese and the Caucasian population, and to derive chemical specific adjustment factors (CSAFs) by integrating variation …

2019-09-11GezondheidArtikel

Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds

Peter I. Racza (Onderzoeker); Marjolein Wildwater (Onderzoeker); Martijn Rooseboom (Onderzoeker); Engelien Kerkhof (Onderzoeker); Raymond Pieters (Lector); Elena Santidrian Yebra-Pimentela (Onderzoeker); Ron P. Dirks (Onderzoeker); Herman P. Spaink (Onderzoeker); Chantal Smulders (Onderzoeker); Graham F. Whale (Onderzoeker)

From the article: "To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening assays need to be translational to humans, have …

2017-06-27GezondheidArtikel

Human lung epithelial cell cultures for analysis of inhaled toxicants

P.S. Hiemstra (Onderzoeker); G. Grootaers (Onderzoeker); A.M. van der Does (Onderzoeker); Cyrille Krul (Lector); Ingeborg M. Kooter

doi: 10.1016/j.tiv.2017.11.005 / PMID:29155131

2017GezondheidArtikel

Toxicity assessment of air-delivered particle-bound polybrominated diphenyl ethers

Luthe, G. (Gregor) (Lector)

Human exposure to polybrominated diphenyl ethers (PBDEs) can occur via ingestion of indoor dust, inhalation of PBDE-contaminated air and dust-bound PBDEs. However, few studies have examined the pulmonary toxicity of particle-bound PBDEs, mainly due to the lack of an appropriate particle-cell exposure …

2014-01-01AlgemeenArtikel

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