Multi-layer cell constructs produced in vitro are an innovative treatment option to support the growing demand for therapy in regenerative medicine. Our research introduces a novel construct integrating organ-derived decellularised extracellular matrix (dECM) hydrogels and 3D-printed biodegradable polymer …

Peripheral nerve injuries (PNIs) are both prevalent throughout society and challenging to treat, especially when the injury is large (> 5mm). When treated unsuccessfully, PNIs often result in significantly diminished quality of life, providing strong motivation for finding reliable treatment procedures. …

The primary cause of death in breast cancer cases is often metastasis, the spread of cancer cells systemically and the formation of secondary tumors in distant organs of the body. The invasion of breast tumor cells into the surrounding tissue is an initial step in the metastatic cascade. In addition …

Klotho knock-out mice are an important model for vascular calcification, which is associated with chronic kidney disease. In chronic kidney disease, serum magnesium inversely correlates with vascular calcification. Here we determine the effects of serum magnesium on aortic calcification in Klotho knock-out …

Study Type – Aetiology (individual cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular …