BACKGROUND: People with Alzheimer's disease (AD) experience, in addition to the progressive loss of cognitive functions, a decline in functional performance such as mobility impairment and disability in activities of daily living (ADL). Functional decline in dementia is mainly linked to the progressive …

Paratonia, a distinctive form of hypertonia in patients with dementia, causes loss of functional mobility in early stage dementia to severe contractures and pain in the late stages. The pathogenesis of paratonia is not well understood. Patients in early stage dementia with diabetes mellitus showed a …

Diminishing motor function is commonly observed in the elderly population and is associated with a wide range of adverse health consequences. Advanced Glycation End products (AGE’s) may contribute to age-related decline in the function of cells and tissues in normal ageing. Although the negative effect …

Meer dan 10 jaar onderzoek naar paratonie heeft al veel opgeleverd. We weten nu dat passief mobiliseren niet effectief is. ook weten we dat paratonie al in een vroeg stadium van dementie aanwezig kan zijn en dat mensen met dementie en diabetes bijna 11 keer meer kans maken om paratonie te ontwikkelen. …