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Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells

Roelofs, Anke J.; Hulley, Philippa A.; van der Heij-Meijer, Annemieke; Ebetino, Frank H.; Russell, R. Graham G.; Shipman, Claire M.

Bisphosphonates (BPs) are widely used in the treatment of osteolytic bone disease associated with multiple myeloma, and have been demonstrated to exert antitumor effects both in vitro and in vivo. However, the precise molecular mechanisms involved in the direct antitumor effects of BPs in vitro are not …

2006-04-17AlgemeenArtikel

Identification of two types of protein immunochemically related to urinary urokinase occurring in human plasma

Binnema, D J; Dooijewaard, G; van Iersel, J J

Plasma urokinase, a plasminogen activator immunochemically related to urinary urokinase (UK), was removed from human plasma (3.5 ng/ml) by immuno-depletion with antibodies raised against UK. The remaining plasminogen activator activity of the depleted plasma could not be inhibited by anti-UK antibodies …

1987-01-15AlgemeenArtikel

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Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells

Identification of two types of protein immunochemically related to urinary urokinase occurring in human plasma

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