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SLC34A2-ROS1 L2026M+G2032R confers resistance to ROS1 tyrosine kinase inhibitors in Ba/F3 cells through a reduced ATP binding pocket volume

Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Vilachã, Juliana F.; Smelt, Maaike; van der Wekken, Anthonie; van den Berg, Anke; Drayer, Lyndsay

2023GezondheidConferentiebijdrage

Development of SARS-COV-2 inhibitors by fragment based drug discovery

Anne van der Sluis (Student)

The coronavirus disease-19 (COVID-19) pandemic still poses serious threats to global public health. Therefore, the scientific community is desperately looking for suitable vaccines and pharmacological treatment options. This thesis completes the internship at Specs Compound Handling BV and describes …

2021-06-16GezondheidBachelor

Moving from intermodal to synchromodal transport: a maturity model applied to a case study in Northwestern Europe

K.M.R. (Kristel) Alons-Hoen; Guy Somers; J.H.R. van Duin

In order to meet emission targets for 2050 in Europe transport needs to be executed more efficiently. A promising way to make transport more efficient is synchromodal transport. When the service provider has more flexibility to arrange transport, the utilization and use of intermodal transport, such …

2019-01-14Bouw & LogistiekArtikel

Moving from intermodal to synchromodal transport: a maturity model applied to a case study in Northwestern Europe (presentation)

K.M.R. (Kristel) Alons-Hoen; Guy Somers; J.H.R. van Duin

2019-01-14Bouw & LogistiekConferentiebijdrage

Overexpression of delta-12 desaturase in the yeast Schwanniomyces occidentalis enhances the production of linoleic acid.

Dennis Lamers; Bram Visscher; R.A. Weusthuis; Christof Francke; R.H. Wijffels; Christien Lokman

The oleaginous yeast Schwanniomyces occidentalis was previously isolated because of its excellent suitability to convert lignocellulosic hydrolysates into triacyl glycerides: it is able to use a broad range of sugars and is able to tolerate high concentrations of lignocellulosic hydrolysate inhibitors. …

2019AlgemeenArtikel

Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU

SUP-ICU trial group

BACKGROUND: Prophylaxis for gastrointestinal stress ulceration is frequently given to patients in the intensive care unit (ICU), but its risks and benefits are unclear. METHODS: In this European, multicenter, parallel-group, blinded trial, we randomly assigned adults who had been admitted to the ICU …

2018-12-06AlgemeenArtikel

Clinical safety of combined therapy of immune checkpoint inhibitors and Viscum album L. therapy in patients with advanced or metastatic cancer

Anja Thronicke (Onderzoeker); Megan L. Steele (Onderzoeker); Christian Grah (Onderzoeker); Burkhard Matthes (Onderzoeker); Friedemann Schad (Onderzoeker)

Background: Despite improvement of tumour response rates in patients with progressive and metastatic cancer, immune checkpoint inhibitors (ICM) induce toxicities in cancer patients. Viscum album L. (VA, mistletoe) extracts are applied as add-on cancer therapy especially in German speaking countries and …

2017-12-13GezondheidArtikel

Synthesis of C-1 Fluorinated Methyl Deoxythymidine-α-diphosphate-β-L-rhamnose Analogues as Inhibitors of Nucleotidylyl- and Rhamnosyltransferases.

Sherany Winter (Student)

Het is bekend dat bacteriën resistent worden tegen recent gebruikte antibiotica, dit resulteert in een vraag naar nieuwe medicijnen. Rhamnose is een 6-deoxy-L-suiker en vormt een belangrijk onderdeel van de bacteriële celwand. De biosynthese van deze suiker vindt alleen op natuurlijke wijze in bacteriën …

2016-11-25TechniekBachelor

Association of proton pump inhibitor use with recurrent falls and risk of fractures in older women: a study of medication use in older fallers

H.W. Thaler; C.S. Sterke; T.J.M. van der Cammen

Objectives To examine the association between Proton pump inhibitors (PPIs) use and falls and fractures. Design A cross-sectional study. Setting and participants 400 female patients aged 70 years or older who were consecutively admitted to the Trauma Center Meidling, Vienna, after a fall and who required …

2016-01-08GezondheidArtikel

Stop or Go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre non-inferiority randomized controlled trial

H. Burger; N.M. Molenaar; H.W. Torij (Lector); G.J. Bonsel; M.P. Lambregtse - van den Berg; W.J.G. Hoogendijk; M.E. Brouwer; C.L.H. Bockting; J.J. Duvekot; C.N. van der Veere

Approximately 6.2% of women in the USA and 3.7% of women in the UK, use Selective Serotonin Reuptake Inhibitors (SSRIs) during their pregnancies because of depression and/or anxiety. In the Netherlands, this prevalence is around 2%. Nonetheless, SSRI use during pregnancy is still controversial. On the …

2016-01-01GezondheidArtikel

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