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Computed tomography reference values for visceral obesity and increased metabolic risk in a Caucasian cohort

Baggerman, Michelle R; Dekker, Ingeborg M; Winkens, Bjorn; Olde Damink, Steven W M; Weijs, Peter J M (Lectoraat Voeding En Beweging); van de Poll, Marcel C G

BACKGROUND: Visceral obesity is associated with the metabolic syndrome. The metabolic risk differs per ethnicity, but reference values for visceral obesity for body composition analyses using Computed Tomography (CT) scans in the Caucasian population are lacking. Therefore, the aim of this study was …

2022-04AlgemeenArtikel

Association of early positive end-expiratory pressure settings with ventilator-free days in patients with coronavirus disease 2019 acute respiratory distress syndrome

BACKGROUND : There is uncertainty about how much positive end-expiratory pressure (PEEP) should be used in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). OBJECTIVE : To investigate whether a higher PEEP strategy is superior to a lower PEEP strategy …

2021-12AlgemeenArtikel

GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

Heeres, André; van der Hoek, Sjoukje; Antunes, Inês F.; Attia, Khaled A.; Jacquet, Olivier; Bulthuis, Marian; Zijlma, Rolf; Boersma, Hendrikus H.; van Goor, Harry; Visser, Ton J.; Heerspink, Hiddo J. L.; Elsinga, Philip H.; Stevens, Jasper

Inhibition of the sodium−glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

2021-11-08AlgemeenArtikel

GMP Compliant Synthesis of [18F]Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

van der Hoek, Sjoukje; Antunes, Inês F.; Attia, Khaled A.; Jacquet, Olivier; Heeres, André; Bulthuis, Marian; Zijlma, Rolf; Boersma, Hendrikus H.; van Goor, Harry; Visser, Ton J.; Heerspink, Hiddo J. L.; Elsinga, Philip H.; Stevens, Jasper

Inhibition of the sodium–glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

2021-11-08AlgemeenArtikel

Virtual Reality Simulation LUMC

Boros, MB (Malina) (Student)

During the graduation period, I have worked with Leiden University Medical Center on bringing to reality the first steps to creating a complementary training tool for their residents. As a result, together with an IMT&S team, we designed and created a demo application which simulates a kidney transplant …

2021-06-01ICT & MediaBachelor

PRactice of VENTilation in Patients with Novel Coronavirus Disease (PRoVENT-COVID)

Boers, Noor S.; Botta, Michela; Tsonas, Annisa M.; Algera, Anna Geke; Pillay, Janesh; Dongelmans, Dave A.; Horn, Janneke; Vlaar, Alexander P. J.; Hollmann, Markus W.; Bos, Lieuwe D. J.; Paulus, Frederique (Lectoraat Critical Care); Neto, Ary Serpa; Schultz, Marcus J.

Background: The coronavirus disease 2019 (COVID-19) pandemic is rapidly expanding across the world, with more than 100,000 new cases each day as of end-June 2020. Healthcare workers are struggling to provide the best care for COVID-19 patients. Approaches for invasive ventilation vary widely between …

2020-10AlgemeenArtikel

Bundled care in acute kidney injury in critically ill patients, a before-after educational intervention study

Koeze, Jacqueline; van der Horst, Iwan C C; Wiersema, Renske; Keus, Frederik; Cox, Eline G M; Zijlstra, Jan G; van Meurs, Matijs; Dieperink, Willem

BACKGROUND: Acute kidney injury (AKI) often occurs in critically ill patients. AKI is associated with mortality and morbidity. Interventions focusing on the reduction of AKI are suggested by the Kidney Disease: Improving Global Outcomes guideline. We hypothesized that these educational interventions …

2020-09-03AlgemeenArtikel

Renal Trapping in Accidental Metformin Intoxication

Posma, Rene A; Wessels, A Mireille A; Dieperink, Willem; Roggeveld, Jan; Leuvenink, Henri G D; van der Horst, Iwan C C; den Dunnen, Wilfred F A; Nijsten, Maarten W; Touw, Daan J

2020-09AlgemeenArtikel

Wat zijn de voor- en nadelen van Renale Tumor Biopsie bij Small Renal Masses in het Martini Ziekenhuis

Maartje Krebbeks (Student); Sylvia Dik (Student); Janine Baër (Begeleider); Priya Dewansingh-Leeffers (Begeleider)

Sinds 7 jaar wordt een nieuw beleid gehanteerd omtrent een SRM (Small Renal Mass). Van de tumor wordt nu eerst een RTB (Renale Tumor Biopsie) genomen om te beoordelen of de tumor maligne of benige is. Met dit praktijkgericht onderzoek wordt een aanbeveling gedaan of het nieuwe beleid toereikend is. De …

2020-06-30GezondheidBachelor

Magnesium prevents vascular calcification in Klotho deficiency

Alkema, Wynand

Klotho knock-out mice are an important model for vascular calcification, which is associated with chronic kidney disease. In chronic kidney disease, serum magnesium inversely correlates with vascular calcification. Here we determine the effects of serum magnesium on aortic calcification in Klotho knock-out …

2020-03-01AlgemeenArtikel

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