RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

Because major depressive disorder (MDD) has a strong negative impact on patients' lives, well–designed treatment programs are needed that address the lasting effects of MDD. Previous work has shown that such programs should not only focus on symptomatic recovery, but also on the subsequent personal recovery …

Across Europe, Jewish museums are housed in former synagogues, representing Jewish religious life through exhibits of ceremonial collections. Besides the absences of active communities of users and liturgical practices, the multi-layered meaning of these spaces and objects contribute to these narrative …

The Lectorate Theology of the CHE focusses on the interpretation and communication of ‘salvation’ within new faith communities. The goal of the Lectorate is to find new ways for contextualizing the Gospel in our secular society, through investigating theologies and processes of sense-making in emerging …

Data-driven modeling is an imperative tool in various industrial applications, including many applications in the sectors of aeronautics and commercial aviation. These models are in charge of providing key insights, such as which parameters are important on a specific measured outcome or which parameter …

Background: The purpose of this study was to investigate the cost-effectiveness and budget impact of the Boston University Approach to Psychiatric Rehabilitation (BPR) compared to an active control condition (ACC) to increase the social participation (in competitive employment, unpaid work, education, …

The booklet describes the renewed Healthy Active Ageing programme, a neighbourhood-oriented health-promoting group programme for and by older people living independently at home. Participants in the programme exchange experiences and knowledge and actively explore topics they consider important, now …

Background: Parents of children with profound intellectual and multiple disabilities (PIMD) have extensive care duties. This study describes the phenomenon “parenting a child with PIMD.” Method: We conducted in-depth interviews with 25 Dutch parents. A reflective lifeworld research. Findings: The …

With a lack of a clear definition, though a normalized use, the discursive weight of the concept of integration is felt throughout policy and civic integration programmes. In wider societal discourse the term integration is used in a taken-for-granted way, with an assumed understanding of its meaning …

Background: Adults with cerebral palsy (CP) may experience an increasing impact of their disability on daily life and this may interfere with their citizenship. Citizenship is a layered construct. Next to formal and theoretical significations, and civil rights acts such as the UN Convention on the Rights …