HBO Kennisbank

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Zocht je misschien: disease, rate, range?

Development and design of a Blueprint for structured transitional care in adolescents and young adults in the academic hospital setting

V. Buijs; M.A.C. van Gaalen; I.K. Schokker-van Linschoten; A.L. van Staa; J.C. Escher

Background and purpose A generic, structured transitional care pathway dedicated to patients in the academic setting is currently lacking. This study aimed to identify the key factors influencing a successful transition from pediatric to adult care for adolescents and young adults and to develop a generic, …

2025-06-26GezondheidArtikel

Nanospresso: torward personalized, locally produced nucleic acid nanomedicines

Wolbers, (Floor) (Onderzoeker); Estape´ Senti, (Mariona ) (Extern); Ceccaldi , A. (Alexandre ) (Extern); Luciani , M. (Marta) (Extern); Saber, N. (Nadine) (Extern); Schurmann, P.J.L. (Paul ) (Extern); Geerlings, M.W. (Maurits ) (Extern); Holig, P. (Peter) (Extern); Beer, J. (Joel) de (Extern); Hannus, M. (Michael ) (Extern); Campbell, F. (Fred) (Extern); Winter, M. (Martin) (Extern); Hoeve, W. (Wim) van (Extern); Westerik, M. (Maurits) (Extern); Dorst-Mooiman, K. (Kim) (Extern); Dekker, J. (Jan) (Extern); Fuchs, S. (Sabine) (Extern); Segers, T. (Tim) (Extern); IJzerman, M. (Maarten) (Extern); Barriga, H.M.G. (Hanna ) (Extern); Bruin, M.L. (Marie ) De (Extern); Even Borgos, S. (Sven ) (Extern); Stevens, M.M. (Molly ) (Extern); Cullis, P. (Pieter ) (Extern); Schiffelers, R.M. ( Raymond ) (Extern)

The NANOSPRESSO project is a pioneering response to the complex challenge of treating orphan diseases, which, despite affecting millions of people globally, have only scant therapeutic options. This initiative represents a paradigm shift by decentralizing the production of personalized nucleic acid nanomedicines. Integrating …

2025-06-26AlgemeenArtikel

Healthcare needs, expectations, utilization, and experienced treatment effects in patients with hereditary spastic paraplegia: a web-based survey in the Netherlands

Hans Kerstens; B.J.H. van Lith; M.J. Nijkrake; Bert de Swart; LAC van den Bemd; RJEM Smeets; F Klemens; BPC van de Warrenburg; P.J. van der Wees; A.C.H. Geurts

Background We aimed to identify healthcare needs, expectations, utilization, and the experienced treatment effects in a population of Dutch patients with hereditary spastic paraplegia (HSP). Methods We distributed an online questionnaire among 194 adult persons with HSP in the Netherlands, of which 166 …

2021AlgemeenArtikel

Experienced complaints, activity limitations and loss of motor capacities in patients with pure hereditary spastic paraplegia: a web-based survey in the Netherlands

B.J.H. van Lith; Hans Kerstens; LAC van den Bemd; Ria Nijhuis-van der Sanden; V. Weerdesteyn; R.J.E.M. Smeets; K Fheodoroff; BPC van de Warrenburg; A.C.H. Geurts

Background Hereditary spastic paraplegia (HSP) is a group of inherited disorders characterized by progressive spastic paresis of the lower limbs. Treatment is often focused on reducing spasticity and its physical consequences. To better address individual patients' needs, we investigated a broad range …

2020AlgemeenArtikel

Het opzetten van een ELISA om auto-antistoffen tegen Factor H te detecteren & De ontwikkeling van een stabiele ELISA standaard door middel van de chimerisatie van een anti-Factor H mAb

Bas van Aalst (Student)

Since Factor H is the main regulator of the complement system, any dysregulation may result in either uncontrolled complement activation or inhibition. Auto-antibodies against Factor H inhibit the protective function of Factor H on host cells, which are now sensitive for complement activation. It is …

2016-11-28Gezondheid; …Bachelor

Evidence for and cost‐effectiveness of physiotherapy in haemophilia: a Dutch perspective

Piet de Kleijn; Eveline P. Mauser-Bunschoten; K. Fischer; C. Smit; Herman H. Holtslag; Cindy Veenhof (Lector)

Musculoskeletal impact of haemophilia justifies physiotherapy throughout life. Recently the Dutch Health Care Institute constrained their ‘list of chronic conditions’, and withdrew financial coverage of physiotherapy for elderly persons with haemophilia (PWH). This decision was based on lack of scientific …

2016GezondheidArtikel

Clinical Pain in Schizophrenia: A Systematic Review

Gwenda Engels; Anneke L. Francke; Berno van Meijel (Lector); Johanna Douma; Heidi de Kam; Wubbien Wesselink; Wim Houtjes (Lid Lectoraat); Erik Scherder

Studies about clinical pain in schizophrenia are rare. Conclusions on pain sensitivity in people with schizophrenia are primarily based on experimental pain studies. This review attempts to assess clinical pain, that is, everyday pain without experimental manipulation, in people with schizophrenia. PubMed, …

2014-05-01Mens & MaatschappijArtikel

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