Aanleiding Chronische nierschade zonder dialyse, verder in dit onderzoek CNS genoemd, komt bij ruim 1 op de 10 Nederlanders voor. Bij de huidige kenmerken in de dieetbehandeling van CNS speelt de eiwitinname een grote rol. Er wordt vooral gefocust op de totale eiwitinname en niet op de eiwitbron. Er …

Introduction: Age-related decline in physical performance causes longer hospitalization and higher mortality rates. The role various micronutrients have on this has been broadly researched, yet a clear overview of current literature’s consensus lacks. Therefore, this narrative review investigatesthe …

BACKGROUND: Acute kidney injury (AKI) often occurs in critically ill patients. AKI is associated with mortality and morbidity. Interventions focusing on the reduction of AKI are suggested by the Kidney Disease: Improving Global Outcomes guideline. We hypothesized that these educational interventions …

Purpose: Exercise therapy with a focus on muscle strengthening has proven to be effective for the management of knee osteoarthritis (OA). Yet it is not known whether high-intensity resistance training (RT) is more effective in improving upper leg muscle strength and physical performance than low-intensity …

Klotho knock-out mice are an important model for vascular calcification, which is associated with chronic kidney disease. In chronic kidney disease, serum magnesium inversely correlates with vascular calcification. Here we determine the effects of serum magnesium on aortic calcification in Klotho knock-out …

BACKGROUND: In critical care patients, reaching optimal β-lactam concentrations poses challenges, as infections are caused more often by microorganisms associated with higher MICs, and critically ill patients typically have an unpredictable pharmacokinetic/pharmacodynamic profile. Conventional intermittent …

It can be concluded that the HBM4EU serum sample preparation method is suitable for Effect-Directed Analysis. The method allows a recovery of all bioactive compounds of interest from serum in the EDA products, with little loss of compounds: bioassay spectra and chromatograms. Nevertheless, the HBM4EU …

Background: A chronic low-grade infammatory profle (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for efects of nutritional supplementation on CLIP is limited. Aim To investigate whether 13 weeks of nutritional supplementation …

Background & aims Plasma citrulline concentration is considered to be a marker for enterocyte metabolic mass and to reflect its reduction as may occur during intestinal dysfunction. Strenuous exercise can act as a stressor to induce small intestinal injury. Our previous studies suggest that this comprises …

Doelstelling: Onderzoeken of autologe serum (AS) oogdruppels een alternatief zouden kunnen zijn voor de huidige kunsttranen (KT) bij droge ogen. Methode: Voor deze literatuurstudie is gebruik gemaakt van de databank Pubmed. Er zijn drie artikelen gebruikt die geselecteerd zijn uit 45 artikelen op …