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L2026M+G2032R variant confers resistance to ROS1 tyrosine kinase inhibitors in SCL34A2-ROS1 overexpressing Ba/F3 cells through a reduced ATP binding pocket volume

Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Vilachã, Juliana F.; Smelt, Maaike; van der Wekken, Anthonie; van den Berg, Anke; Drayer, Lyndsay

Background The ROS1 G2032R mutation is the most common on-target resistance mutation in crizotinib treated ROS1-positive lung cancer patients. The aim of our study was to investigate resistance mechanisms in SCL34A2-ROS1G2032R positive Ba/F3 cells against second line treatment with lorlatinib. Methods …

2023-10-21GezondheidConferentiebijdrage

Extraintestinal pathogenic Escherichia coli sequence type 131 H30-R and H30-Rx subclones in retail chicken meat, Italy

Arash Ghodousi (Onderzoeker); Celestino Bonura (Onderzoeker); Paola di Carlo (Onderzoeker); Willem van Leeuwen (Lector); Caterina Mammina (Onderzoeker)

Extraintestinal pathogenic Escherichia coli sequence type 131 (ST131), typically fluoroquinolone-resistant (FQ-R) and/or extended-spectrum β-lactamase (ESBL)-producing, has emerged globally. Among clinical isolates, ST131, primarily its H30-R and H30-Rx subclones, accounts for most antimicrobial-resistant …

2016-04-06Natuur & LandbouwArtikel

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L2026M+G2032R variant confers resistance to ROS1 tyrosine kinase inhibitors in SCL34A2-ROS1 overexpressing Ba/F3 cells through a reduced ATP binding pocket volume

Extraintestinal pathogenic Escherichia coli sequence type 131 H30-R and H30-Rx subclones in retail chicken meat, Italy

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