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Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes

Monique van der Voet (Onderzoeker); Marc Teunis (Associate Lector); Johanna Louter-Van de Haar (Onderzoeker); Nienke Stigter (Onderzoeker); Diksha Balla (Onderzoeker); Martijn Rooseboom (Onderzoeker); Kimberley Wever (Onderzoeker); Cyrille Krul (Lector); Raymond Pieters (Lector); Marjolein Wildwater (Onderzoeker); Vera van Noort (Onderzoeker)

Implementation of reliable methodologies allowing Reduction, Refinement, and Replacement (3Rs) of animal testing is a process that takes several decades and is still not complete. Reliable methods are essential for regulatory hazard assessment of chemicals where differences in test protocol can influence …

2021GezondheidArtikel

Socio‐Environmental Vulnerability Mapping for Environmental and Flood Resilience Assessment

Szymon Szewranski; Malgorzata Swiader; Jan K. Kazak; Katarzyna Tokarczyk-Dorociak; Joost van Hoof (Lector)

The phenomena of urbanization and climate change interact with the growing number of older people living in cities. One of the effects of climate change is an increased riverine flooding hazard, and when floods occur this has a severe impact on human lives and comes with vast economic losses. Flood …

2018-06-18Mens & Maatschappij; …Artikel

Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds

Peter I. Racza (Onderzoeker); Marjolein Wildwater (Onderzoeker); Martijn Rooseboom (Onderzoeker); Engelien Kerkhof (Onderzoeker); Raymond Pieters (Lector); Elena Santidrian Yebra-Pimentela (Onderzoeker); Ron P. Dirks (Onderzoeker); Herman P. Spaink (Onderzoeker); Chantal Smulders (Onderzoeker); Graham F. Whale (Onderzoeker)

From the article: "To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening assays need to be translational to humans, have …

2017-06-27GezondheidArtikel

Work participation of patients with musculoskeletal disorders: is this addressed in physical therapy practice?

Wiebke Oswald; Nathan Hutting; Josephine Engels; Bart Staal; Ria Nijhuis-van der Sanden; Yvonne Heerkens

BACKGROUND: Musculoskeletal disorders are the main complaints for visiting a physical therapist (PT) in primary health care; they have a negative effect on an individual's quality of life and result in a major cost to society. Qualitative research has shown that physical therapists (PTs) treating patients …

2017AlgemeenArtikel

Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects

Sonja Beken; Peter T. Theunissen (Lid Lectoraat); Bruce K. Beyer

nd co-authors , William J. Breslin, Gregg D. Cappon, Connie L. Chen, Gary Chmielewski, Luc De Schaepdrijver, Brian Enright, Jennifer E. Foreman, Wafa Harrouk, Kok-Wah Hew, Alan M. Hoberman, Julia Y. Hui, Thomas B. Knudsen, Susan B. Laffan, Susan L. Makris, Matt Martin, Mary Ellen McNerney, Christine …

2016-10-19Gezondheid; …Artikel

Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data

Mirjam Luijten; Jan van Benthem; E.D. Kroese; Ruud A. Woutersen; Cyrille A.M. Krul (Lector); Ans E.M.F. Soffers; Jan Willem van der Laan

From the article: Abstract Sub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predict the tumour outcome of 24-month rat carcinogenicity studies obtained from the EFSA and ToxRef databases. Hundred eleven of the 148 chemicals that did not induce putative preneoplastic …

2016-09-08Gezondheid; …Artikel

Validation; truth or dare! [Abstract].

Marc Teunis (Lid Lectoraat); Cyrille Krul (Lector); Raymond Pieters (Lector)

n.a.

2015-10-16Natuur & LandbouwArtikel

Role of the immune system in DILI

Raymond Pieters (Lector)

n.a. doi:10.1016/j.toxlet.2015.08.109

2015-10-16Techniek; …Artikel

Validation of the innovative ToxTracker® genotoxicity reporter assay

Marc Teunis (Lid Lectoraat); Mieke Smits (Lid Lectoraat); H. Besselink; L.R.A. Jonker; G. Hendriks; E Adriaens

2015-09-29Gezondheid; …Recensie

Development of a self-management intervention for employees with complaints of the arm, neck and/or shoulder (CANS): a focus group study with experts.

Nathan Hutting; Josephine Engels; Bart Staal; Yvonne Heerkens; Ria Nijhuis-van der Sanden

BACKGROUND: Many people suffer from complaints of the arm, neck and/or shoulder (CANS). The complaints are persistent and there is a need for intervention programs for those with longstanding CANS. Studies suggest that a behavioural change is needed in employees with CANS. A self-management program with …

2015AlgemeenArtikel

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