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Repeated-Dose Toxicity, Biodistribution, and Shedding Assessments With a ChAd155 Respiratory Syncytial Virus Vaccine Candidate Evaluated in Rabbits and Rats

AH Stokes; C Planty; J Pion; P Ancian; A Rogue; C Bansard; J Silvano; D Papineau; N Ben Abdeljelil; G Maruggi; HF Song; C Spickler; K Blouin; G Dubois; LA Rodriguez; J Baumeister; AM Steff; E Destexhe

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (LRTI) in infants, and toddlers and vaccines are not yet available. A pediatric RSV vaccine (ChAd155-RSV) is being developed to protect infants against RSV disease. The ChAd155-RSV vaccine consists of a recombinant …

2022AlgemeenArtikel

Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies

Marie Corradi (Onderzoeker); Alyanne M. de Haan (Onderzoeker); Bernard Staumont (Onderzoeker); Aldert H. Piersma (Onderzoeker); Liesbet Geris (Onderzoeker); Raymond H.H. Pieters (Lector); Cyrille A.M. Krul (Lector); Marc A.T. Teunis (Onderzoeker)

Adverse Outcome Pathways (AOPs) are conceptual frameworks that tie an initial perturbation (molecular initiat- ing event) to a phenotypic toxicological manifestation (adverse outcome), through a series of steps (key events). They provide therefore a standardized way to map and organize toxicological …

2022Gezondheid; …Artikel

Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes

Monique van der Voet (Onderzoeker); Marc Teunis (Associate Lector); Johanna Louter-Van de Haar (Onderzoeker); Nienke Stigter (Onderzoeker); Diksha Balla (Onderzoeker); Martijn Rooseboom (Onderzoeker); Kimberley Wever (Onderzoeker); Cyrille Krul (Lector); Raymond Pieters (Lector); Marjolein Wildwater (Onderzoeker); Vera van Noort (Onderzoeker)

Implementation of reliable methodologies allowing Reduction, Refinement, and Replacement (3Rs) of animal testing is a process that takes several decades and is still not complete. Reliable methods are essential for regulatory hazard assessment of chemicals where differences in test protocol can influence …

2021GezondheidArtikel

New approach methodologies (NAMs) for human-relevant biokinetics predictions

Punt, A.; Bouwmeester, H.; Blaauboer, B.J.; Strikwold, M. (Lector)

For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion (ADME/biokinetics) in chemical risk evaluations are a bottleneck. To enhance the field, a team …

2020-06-08GezondheidArtikel

Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone

Shi, M.; Bouwmeester, H.; Rietjens, I.M.C.M.; Strikwold, M. (Associate Lector)

Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data …

2020-05-04GezondheidArtikel

Integrating physiologically based kinetic (PBK) and Monte Carlo modelling to predict inter-individual and inter-ethnic variation in bioactivation and liver toxicity of lasiocarpine

Ning, J.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

The aim of the present study was to predict the effect of inter-individual and inter-ethnic human kinetic variation on the sensitivity towards acute liver toxicity of lasiocarpine in the Chinese and the Caucasian population, and to derive chemical specific adjustment factors (CSAFs) by integrating variation …

2019-09-11GezondheidArtikel

Socio‐Environmental Vulnerability Mapping for Environmental and Flood Resilience Assessment

Szymon Szewranski; Malgorzata Swiader; Jan K. Kazak; Katarzyna Tokarczyk-Dorociak; Joost van Hoof (Lector)

The phenomena of urbanization and climate change interact with the growing number of older people living in cities. One of the effects of climate change is an increased riverine flooding hazard, and when floods occur this has a severe impact on human lives and comes with vast economic losses. Flood …

2018-06-18Mens & Maatschappij; …Artikel

Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds

Peter I. Racza (Onderzoeker); Marjolein Wildwater (Onderzoeker); Martijn Rooseboom (Onderzoeker); Engelien Kerkhof (Onderzoeker); Raymond Pieters (Lector); Elena Santidrian Yebra-Pimentela (Onderzoeker); Ron P. Dirks (Onderzoeker); Herman P. Spaink (Onderzoeker); Chantal Smulders (Onderzoeker); Graham F. Whale (Onderzoeker)

From the article: "To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening assays need to be translational to humans, have …

2017-06-27GezondheidArtikel

Work participation of patients with musculoskeletal disorders: is this addressed in physical therapy practice?

Wiebke Oswald; Nathan Hutting; Josephine Engels; Bart Staal; Ria Nijhuis-van der Sanden; Yvonne Heerkens

BACKGROUND: Musculoskeletal disorders are the main complaints for visiting a physical therapist (PT) in primary health care; they have a negative effect on an individual's quality of life and result in a major cost to society. Qualitative research has shown that physical therapists (PTs) treating patients …

2017AlgemeenArtikel

Human lung epithelial cell cultures for analysis of inhaled toxicants

P.S. Hiemstra (Onderzoeker); G. Grootaers (Onderzoeker); A.M. van der Does (Onderzoeker); Cyrille Krul (Lector); Ingeborg M. Kooter

doi: 10.1016/j.tiv.2017.11.005 / PMID:29155131

2017GezondheidArtikel

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