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Feasibility Study to Assess Canagliflozin Distribution and Sodium-Glucose Co-Transporter 2 Occupancy Using [18F]Canagliflozin in Patients with Type 2 Diabetes

van der Hoek, Sjoukje; Willemsen, Antoon T.M.; Visser, Ton; Heeres, Andre; Mulder, Douwe J.; Bokkers, Reinoud P.H.; Slart, Riemer H.J.A.; Elsinga, Philip H.; Heerspink, Hiddo J.L.; Stevens, Jasper

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, including canagliflozin, reduce the risk of cardiovascular and kidney outcomes in patients with and without type 2 diabetes, albeit with a large interindividual variation. The underlying mechanisms for this variation in response might be attributed …

2023-03-10AlgemeenArtikel

JMIR artikel

Bults, (Marloes) (Onderzoeker); Ouden, (Marjolein) den (Lector); Leersum, (Catharina ) van (Extern); Olthuis, (Theodorus) (Lector); Bekhuis, (Robin) (Extern)

This study provides an in-depth understanding of the perceptions of patients with T2DM before use (acceptability) and after use (acceptance) regarding 4 different mobile health apps for diabetes control and self-management. This study was part of the TOPFIT Citizenlab project. TOPFIT Citizenlab is a …

2023-01-01AlgemeenArtikel

Additional effects of exercise to hypocaloric diet on body weight, body composition, glycaemic control, and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes: a systematic review and meta-analysis

Memelink, Robert (Lectoraat Voeding En Beweging); Hummel, Mitchell; Hijlkema, Aveline; Streppel, Martinet (Lectoraat Voeding En Beweging); Bautmans, Ivan; Weijs, Peter (Lectoraat Voeding En Beweging); Berk, Kirsten; Tieland, Michael (Lectoraat Voeding En Beweging)

BACKGROUND This systematic review and meta-analysis evaluates the additional effects of exercise to hypocaloric diet on body weight, body composition, glycaemic control, and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes. METHODS Embase, Medline, Web of Science, and …

2022-11AlgemeenConferentiebijdrage

Studying Telmisartan Plasma Exposure, Kidney Distribution, Receptor Occupancy, and Response in Patients With Type 2 Diabetes Using [11C]Telmisartan

van der Hoek, Sjoukje; Mulder, Douwe J.; T.M. Willemsen, Antoon; Visser, Ton J.; Heeres, André; Slart, Riemer H.J.A.; Elsinga, Philip H.; Heerspink, Hiddo J. L.; Stevens, Jasper

The angiotensin receptor blocker telmisartan slows progression of kidney disease in patients with type 2 diabetes (T2D), yet many patients remain at high risk for progressive kidney function loss. The underlying mechanisms for this response variation might be attributed to differences in angiotensin-1 …

2022-09-07AlgemeenArtikel

Barriers and Drivers Regarding the Use of Mobile Health Apps Among Patients With Type 2 Diabetes Mellitus in the Netherlands: Explanatory Sequential Design Study

Bults, (Marloes) (Onderzoeker); Leersum, C.M. (Catharina ) van (Extern); Olthuis, T.J.J. (Theodorus ) (Extern); Bekhuis, R.E.M. (Robin ) (Extern); Ouden, M. (Marjolein) den (Lector)

andlt;pandgt;Self-monitoring of blood glucose levels, food intake, and physical activity supports self-management of patients with type 2 diabetes mellitus (T2DM). There has been an increase in the development and availability of mobile health apps for T2DM.andlt;/pandgt;

2022-01-01AlgemeenArtikel

Op welke manier zijn eerstelijns diëtisten bereid om fysiotherapeuten te betrekken bij de behandeling van type 2 diabetes patiënten met lichamelijke beperking(en)?

Maya van der Does-Levi (Student)

Type 2 diabetes mellitus (DM2) is een metabolische ziekte waarbij hyperglycemie door onvoldoende insulinesecretie en insulineresistentie het kenmerkende ziekteverschijnsel is. In 2019 telde Nederland circa 1 miljoen DM2 patiënten. De behandeling van DM2 bestaat, naast medicatie, uit het stimuleren van …

2022GezondheidBachelor

Voeding

Tieland, M. (Lectoraat Voeding En Beweging); van den Helder, J. (Lectoraat Voeding En Beweging); van der Spek, N. (Urban Vitality); Benali, M. (Lectoraat Voeding En Beweging); Schoufour, J. D. (Lectoraat Voeding En Beweging); Cambier, Dirk; Hobbelen, Hans; de Vries, Nienke

De vergrijzing neemt toe en een van de belangrijkste zorguitdagingen die daarmee gepaard gaat, is de toenemende prevalentie en incidentie van fysieke en cognitieve beperkingen van oudere volwassenen. Deze fysieke beperkingen hebben grote invloed op de zelfredzaamheid en vergroten de kans op ziekten, …

2022AlgemeenBoekdeel

Transfer in care and diabetes distress in young adults with type 1 diabetes mellitus

J.N.T. Sattoe; M.A.C. Peeters; M.B. Bronner; A.L. van Staa

Introduction: Diabetes distress (DD) is a serious problem in many people with diabetes and is associated with unfavorable clinical and psychosocial outcomes in children and adults. Little is known about DD in young adults (YAs) with type 1 diabetes mellitus (T1DM) who transferred to adult care. This …

2021-12-30GezondheidArtikel

Increased species richness in the oral microbiome by a 13-week protein and combined lifestyle intervention in older adults with obesity and type 2 diabetes

Haji, M.; Memelink, R.G. (Lectoraat Voeding En Beweging); Brandt, B.W.; Buijs, M.J.; Pasman, W.J.; de Vogel-Van den Bosch, J.; Wopereis, S.; Zaura, E.; Weijs, P.J. (Lectoraat Voeding En Beweging)

Rationale: While combined lifestyle interventions have multiple health benefits, their impact on the oral microbiome is not known. We explored the effects of a lifestyle intervention including protein drink on the oral microbiome in older adults with obesity and type 2 diabetes (T2D). Methods: In a post-hoc …

2021-12AlgemeenArtikel

GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

Heeres, André; van der Hoek, Sjoukje; Antunes, Inês F.; Attia, Khaled A.; Jacquet, Olivier; Bulthuis, Marian; Zijlma, Rolf; Boersma, Hendrikus H.; van Goor, Harry; Visser, Ton J.; Heerspink, Hiddo J. L.; Elsinga, Philip H.; Stevens, Jasper

Inhibition of the sodium−glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

2021-11-08AlgemeenArtikel

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