Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to its two pro-apoptotic receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2. Primary components of the DISC are trimerized …

A psycho-organic disorder such as delirium is a frequently occurring and serious disorder especially on Intensive Care units. Nowadays, more attention is paid to this problem by physicians, nurses and by researchers, but assessment of delirium in all ICU patients is still not common practice. If patients …

Background: The feasibility and predictive validity of balance and gait measures in more severe stages of dementia have been understudied. We evaluated the clinimetric properties of the Tinetti Performance Oriented Mobility Assessment (POMA) in nursing home residents with dementia with a specific objective …

OBJECTIVES: Patients with hip or knee osteoarthritis (OA) may experience functional limitations in work settings. In the Cohort Hip and Cohort Knee study (CHECK) physical function was both self-reported and measured performance-based, using Functional Capacity Evaluation (FCE). Relations between self-reported …

The central focus of this article is on the moral dilemmas that social servants face when applying the law. These moral dilemmas result from the professional’s discretionary space. Exploratory qualitative research shows that, in order to solve these dilemmas, professionals in some public organisations …

In de onderstaande samenvatting staat de opzet en inhoud van dit pilot onderzoek beschreven. Daarnaast de conclusies en aanbevelingen. Het pilot onderzoek is uitgevoerd binnen de Pompe kliniek in Nijmegen, wat betreft een TBS kliniek. Binnen deze kliniek wordt over het algemeen veel individuele therapie …

STUDY DESIGN: Meta-analysis. OBJECTIVES: To define the accuracy of clinical tests for assessing anterior cruciate ligament (ACL) ruptures. BACKGROUND: The cruciate ligaments, and especially the ACL, are among the most commonly injured structures of the knee. Given the increasing injury prevalence, there …

The research project ‘In search of pedagogical sensitivity’ is executed from the research department of the knowledge circle ‘renewing methods and didactics for teacher education and training’ of the Hogeschool Utrecht in the Netherlands under supervision of Hans Jansen (associated professor of the Hogeschool …

PURPOSE: To analyse how decisions to dichotomise the frequency and impediment of phantom pain into absent and present influence the outcome of studies by performing a sensitivity analysis on an existing database. METHOD: Five hundred and thirty-six subjects were recruited from the database of an orthopaedic …

This research article shows that a high intensity exercise program compared to a low intensity exercise program of the same session duration and frequency, increases insulin sensitivity to a larger extend in healthy subjects. It also shows that the short insulin tolerance test can be used to detect differences …