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A high whey protein-, leucine-, and vitamin D-enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial.

Verreijen, Amely M; Verlaan, Sjors; Engberink, Mariëlle F; Swinkels, Sophie; de Vogel-van den Bosch, Johan; Weijs, Peter JM (Lectoraat Voeding En Beweging)

BACKGROUND: Intentional weight loss in obese older adults is a risk factor for muscle loss and sarcopenia. OBJECTIVE: The objective was to examine the effect of a high whey protein-, leucine-, and vitamin D-enriched supplement on muscle mass preservation during intentional weight loss in obese older …

2015-02AlgemeenArtikel

Comparison of Six Commercial ELISA Kits for Their Specificity and Sensitivity in Detecting Different Major Peanut Allergens

Julie Nordlee; Aard de Jongh; Joe Baumert; Raymond Pieters (Lector); Steve L. Taylor; Stef J. Koppelman; Shyamali Jayasena; Daniëlle Fiechter (Lid Lectoraat); Mieke Smits (Lid Lectoraat)

Author supplied: "Six commercial peanut enzyme-linked immunosorbent assay kits were assessed for their ability to recover peanut from the standard reference material 2387 peanut butter and also for their specificity in detecting four major peanut allergens, Ara h 1, Ara h 2, Ara h 3, and Ara h 6. The …

2015-01-17GezondheidArtikel

Dietary protein intake in Dutch elderly people

Tieland, Michael (Lectoraat Voeding En Beweging); Borgonjen-Van den Berg, Karin J.; Van Loon, Luc J. C.; de Groot, Lisette C. P. G. M.

INTRODUCTION: Sufficient high quality dietary protein intake is required to prevent or treat sarcopenia in elderly people. Therefore, the intake of specific protein sources as well as their timing of intake are important to improve dietary protein intake in elderly people. OBJECTIVES: to assess the consumption …

2015AlgemeenArtikel

Proteins and amino acids are fundamental to optimal nutrition support in critically ill patients

Weijs, Peter JM; Cynober, Luc; DeLegge, Mark; Kreymann, Georg; Wernerman, Jan; Wolfe, Robert R

In this review, we present the growing scientific evidence showing the importance of protein and amino acid provision in nutritional support and their impact on preservation of muscle mass and patient outcomes.

2014-11-17AlgemeenArtikel

Recommendations for Analyzing and Reporting TP 53 Gene Variants in the High‐Throughput Sequencing Era

Thierry Soussi (Onderzoeker); Bernard Leroy (Onderzoeker); Peter Taschner (Lector)

The architecture of TP 53 , the most frequently mutated gene in human cancer, is more complex than previously thought. Using TP 53 variants as clinical biomarkers to predict response to treatment or patient outcome requires an unequivocal and standardized procedure toward a definitive strategy for the …

2014-04-12GezondheidArtikel

Diversity in robustness of Lactococcus lactis strains during heat stress, oxidative stress, and spray drying stress

Dijkstra, Annereinou R; Setyawati, Meily C; Bayjanov, Jumamurat R; Alkema, Wynand; van Hijum, Sacha A F T; Bron, Peter A; Hugenholtz, Jeroen

In this study we tested 39 Lactococcus lactis strains isolated from diverse habitats for their robustness under heat and oxidative stress, demonstrating high diversity in survival (up to 4 log units). Strains with an L. lactis subsp. lactis phenotype generally displayed more-robust phenotypes than strains …

2014-01-15AlgemeenArtikel

Early high protein intake is associated with low mortality and energy overfeeding with high mortality in non-septic mechanically ventilated critically ill patients

Weijs, Peter JM (Lectoraat Voeding En Beweging); Looijaard, Wilhelmus GPM; Beishuizen, Albertus; Girbes, Armand RJ; Oudemans-van Straaten, Heleen M

Abstract: INTRODUCTION: Early protein and energy feeding in critically ill patients is heavily debated and early protein feeding hardly studied.

2014AlgemeenArtikel

Fundamental determinants of protein requirements in the ICU

Weijs, Peter J.M. (Lectoraat Voeding En Beweging)

PURPOSE OF REVIEW: Currently, feeding the ICU patient is highly discussed. Energy feeding has been the topic of randomized studies, but protein feeding has not. Study results are contradictory on early feeding; however, little is known about early protein requirement. What is this protein requirement …

2014AlgemeenArtikel

Identification of biomarkers to detect residual pertussis toxin using microarray analysis of dendritic cells

R.J. Vandebriel; Saertje Verkoeijen (Lid Lectoraat); A.M. Akkermans; Stefan Vaessen (Lid Lectoraat); M.W.P. Bruysters; J.L.A. Pennings; R. Bos; Cyrille Krul (Lector)

tIn this study we aimed to identify genes that are responsive to pertussis toxin (PTx) and might eventu-ally be used as biological markers in a testing strategy to detect residual PTx in vaccines. By microarrayanalysis we screened six human cell types (bronchial epithelial cell line BEAS-2B, fetal lung …

2013Natuur & LandbouwArtikel

The role of Coproporphyrinogen III oxidase and Ferrochelatase genes in heme biosynthesis and regulation in Aspergillus niger

C.A. van den Hondel; P.J. Punt; H. Haas; Arthur F.J. Ram; M. Werner; S. de Weert; A.C. Franken; Christien Lokman

Heme is a suggested limiting factor in peroxidase production by Aspergillus spp., which are well-known suitable hosts for heterologous protein production. In this study, the role of genes coding for coproporphyrinogen III oxidase (hemF) and ferrochelatase (hemH) was analyzed by means of deletion and …

2013AlgemeenArtikel

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