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Saturation mutagenesis reveals the importance of residues alphaR145 and alphaF146 of penicillin acylase in the synthesis of beta-lactam antibiotics

Jager, Simon A W; Shapovalova, Irina V; Jekel, Peter A; Alkema, Wynand B L; Svedas, Vytas K; Janssen, Dick B

Penicillin acylase (PA) from Escherichia coli can catalyze the coupling of an acyl group to penicillin- and cephalosporin-derived beta-lactam nuclei, a conversion that can be used for the industrial synthesis of beta-lactam antibiotics. The modest synthetic properties of the wild-type enzyme make it …

2008-01-01AlgemeenArtikel

Synthesis, analysis and reduction of 2-nitropropyl starch

Heeres, André; Van Doren, Henk A.; Gotlieb, Kees F.; Bergsma, Jack; Kellogg, Richard M.; Bleeker, Ido Pieter

Granular 2-nitropropyl potato starch was synthesized by reaction with 2-nitropropyl acetate in an aqueous suspension. Nitroalkylation occurs preferentially with the amylose fraction of potato starch, as was confirmed by leaching experiments and digestion of the modified starch with α-amylase. The 2-nitropropyl …

2001-01-30AlgemeenArtikel

Catalytic enantioselective annulations via 1,4-addition - Aldol cyclization of functionalized organozinc reagents [9]

Naasz, Robert; Arnold, Leggy A.; Pineschi, Mauro; Keller, Erik; Feringa, Ben L.

1999-01-26AlgemeenArtikel

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Saturation mutagenesis reveals the importance of residues alphaR145 and alphaF146 of penicillin acylase in the synthesis of beta-lactam antibiotics

Synthesis, analysis and reduction of 2-nitropropyl starch

Catalytic enantioselective annulations via 1,4-addition - Aldol cyclization of functionalized organozinc reagents [9]

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