Background The ROS1 G2032R mutation is the most common on-target resistance mutation in crizotinib treated ROS1-positive lung cancer patients. The aim of our study was to investigate resistance mechanisms in SCL34A2-ROS1G2032R positive Ba/F3 cells against second line treatment with lorlatinib. Methods …

Circular and elliptical motion are fundamental topics in physics education, yet learners often struggle to grasp them. We investigate how interactive qualitative representations can be used to describe the characteristic behavior of circular and elliptical motion. We use the vocabulary and algorithms …

Purpose: A more dynamic school day that includes less sitting and more physical activity throughout the day may support health in primary school children. In this mixed methodologies study, we assessed which physical activity possibilities are incorporated in the school policies of Dutch primary schools …

We developed and tested a teaching case and teaching note on the challenges that a small sustainable fashion brand faces when implementing a circular business model. We target bachelor and master students of international business, entrepreneurship, strategic management, circularity/sustainability courses. …

Purpose Self-initiated expatriates (SIE) women's career decisions are often based on the establishment of close personal relationships in various spheres of life. This paper aims to explore the effects of social isolation in times of crisis on SIE women's work, psychological and general adjustment. Design/methodology/approach …

The built environment requires energy-flexible buildings to reduce energy peak loads and to maximize the use of (decentralized) renewable energy sources. The challenge is to arrive at smart control strategies that respond to the increasing variations in both the energy demand as well as the variable …

Background The gait modification strategies Trunk Lean and Medial Thrust have been shown to reduce the external knee adduction moment (EKAM) in patients with knee osteoarthritis which could contribute to reduced progression of the disease. Which strategy is most optimal differs between individuals, but …

Dynamic inflow effects occur due to the rapid change of the rotor loading under conditions such as fast pitch steps. The paper presents a setup suitable for the investigation of those effects for non-axisymmetric rotor conditions, namely individual pitch steps. Furthermore, insights into the relevant …

Background The closing of schools and sports clubs during the COVID-19 lockdown raised questions about the possible impact on children’s motor skill development. Therefore, we compared motor skill development over a one-year period among four different cohorts of primary school children of which two …

We developed and piloted a course, called Changemakers, that supported interdisciplinary student-led action groups to identify social and environmental sustainability challenges and influence systemic change. By exposing students to dynamic and complex issues from multiple stakeholder perspectives, Changemakers …