Exercise is one of the external factors associated with impairment of intestinal integrity, possibly leading to increased permeability and altered absorption. Here, we aimed to examine to what extent endurance exercise in the glycogen‐depleted state can affect intestinal permeability toward small molecules …

In this thesis the different aspects of acquiring the complex refractive index of interstellar ice analogues are treated. The ultimate aim of this work is to search for abilities to predict the infrared absorption spectra of these analogues. A key factor in these predictions is the optical influence …

Dietary fibers are at the forefront of nutritional research because they positively contribute to human health. Much of our processed foods contain, however, only small quantities of dietary fiber, because their addition often negatively affects the taste, texture, and mouth feel. There is thus an urge …

Probiotic bacteria harbor effector molecules that confer health benefits, but also adaptation factors that enable them to persist in the gastrointestinal tract of the consumer. To study these adaptation factors, an antibiotic-resistant derivative of the probiotic model organism Lactobacillus plantarum …

This thesis describes how the abundance of CO2 a ects the porosity of H2O:CO2 ice mixtures deposited at di erent growth temperatures ranging from 30 - 70 K. The mixing ratios of the used ice samples H2O:CO2 = 10:1, 4:1 and 2:1 are of astrophysical relevance. Laser optical interference is used to monitor …

The Pierre Auger group is studying ultra-high energy cosmic rays. Cosmic rays are charged particles which permanently hit and penetrate the atmosphere of the Earth. They will at a certain moment collide with nuclei in the atmosphere, like nitrogen. The results of such an interaction are new particles, …

This report presents the highlights of the 7th European Meeting on Molecular Diagnostics held in Scheveningen, The Hague, The Netherlands, 12-14 October 2011. The areas covered included molecular diagnostics applications in medical microbiology, virology, pathology, hemato-oncology,clinical genetics …

Background: G-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM) domain. Because of their structural and sequence conservation, the TM domains are often used in bioinformatics …

Genomics has multiplied the number of targets for new therapeutic interventions, but this has not yet lead to a marked increase of pharma pipeline outputs. The complexity of protein function in higher order biological systems is often underestimated. Translation from in vitro and in vivo results to the …

Seven new 1,3,5-cyclohexyltricarboxamide-phenylalanine derivatives were synthesized in order to investigate the effect of the amino acid chirality on the gelating properties of these small molecules in water. Gelation tests have shown that enantiomerically pure homochiral 1,3,5-cyclohexyltricarboxamide-L-phenylalanine …