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Oxygen Consumption with High-Flow Nasal Oxygen versus Mechanical Ventilation—An International Multicenter Observational Study in COVID–19 Patients (PROXY–COVID)

Botta, Michela; Caritg, Oriol; van Meenen, David M.P.; Pacheco, Andrés; Tsonas, Anissa M.; Mooij, Willemijn E.; Burgener, Alessia; Hehl, Tosca Manrique; Shrestha, Gentle S.; Horn, Janneke; Tuinman, Pieter R.; Paulus, Frederique (Lectoraat Critical Care); Roca, Oriol; Schultz, Marcus J.

The COVID–19 pandemic led to local oxygen shortages worldwide. To gain a better understanding of oxygen consumption with different respiratory supportive therapies, we conducted an international multicenter observational study to determine the precise amount of oxygen consumption with high-flow nasal …

2023-05AlgemeenArtikel

Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Nollet, Edgar E; Duursma, Inez; Rozenbaum, Anastasiya; Eggelbusch, Moritz; Wüst, Rob C I; Schoonvelde, Stephan A C; Michels, Michelle; Jansen, Mark; van der Wel, Nicole N; Bedi, Kenneth C Jr; Margulies, Kenneth B; Nirschl, Jeff; Kuster, Diederik W D; van der Velden, Jolanda

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

2023-04-01AlgemeenArtikel

Incidence of Air Leaks in Critically Ill Patients with Acute Hypoxemic Respiratory Failure Due to COVID-19

Goossen, Robin L.; Verboom, Mariëlle; Blacha, Mariëlle; Smesseim, Illaa; Beenen, Ludo F. M.; van Meenen, David M. P.; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.

Subcutaneous emphysema, pneumothorax and pneumomediastinum are well-known complications of invasive ventilation in patients with acute hypoxemic respiratory failure. We determined the incidences of air leaks that were visible on available chest images in a cohort of critically ill patients with acute …

2023-03AlgemeenArtikel

Author's response

Tsonas, Anissa M.; Schultz, Marcus J.; Paulus, Frederique (Lectoraat Critical Care)

2023-02AlgemeenArtikel

Effect of mechanical power on mortality in invasively ventilated ICU patients without the acute respiratory distress syndrome

van Meenen, David M.P.; Algera, Anna Geke; Schuijt, Michiel T.U.; Simonis, Fabienne D.; van der Hoeven, Sophia M.; Neto, Ary Serpa; Abreu, Marcelo Gama de; Pelosi, Paolo; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.

BACKGROUND The mechanical power of ventilation (MP) has an association with outcome in invasively ventilated patients with the acute respiratory distress syndrome (ARDS). Whether a similar association exists in invasively ventilated patients without ARDS is less certain. OBJECTIVE To investigate the …

2023-01AlgemeenArtikel

Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19

Daenen, Katrijn; Huijben, Jilske A; Boyd, Anders; Bos, Lieuwe D J; Stoof, Sara C M; van Willigen, Hugo; Gommers, Diederik A M P J; Moeniralam, Hazra S; den Uil, Corstiaan A; Juffermans, Nicole P; Kant, Merijn; Valkenburg, Abraham J; Pillay, Janesh; van Meenen, David M P; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J; Dalm, Virgil A S H; van Gorp, Eric C M; Schinkel, Janke; Endeman, Henrik

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose …

2023-01AlgemeenArtikel

Respiratory and non-respiratory symptoms in patients with IPF or sarcoidosis and controls

Aadje Bloem (Onderzoeker); Sarah Houben-Wilke (Onderzoeker); Rémy Mostard (Onderzoeker); Naomi Stoot (Onderzoeker); Daisy J. A. Janssen (Onderzoeker); Frits Franssen (Onderzoeker); Jan Custers (Onderzoeker); Martijn A. Spruit (Onderzoeker)

Introduction: Besides dyspnoea and cough, patients with idiopathic pulmonary fibrosis (IPF) or sarcoidosis may experience distressing non-respiratory symptoms, such as fatigue or muscle weakness. However, whether and to what extent symptom burden differs between patients with IPF or sarcoidosis and individuals …

2023GezondheidArtikel

The Association Between Preoperative Inspiratory Muscle Training Variables and Postoperative Pulmonary Complications in Subjects With Esophageal Cancer

Meike Overbeek (Onderzoeker); Elja Reijneveld (Onderzoeker); Karin Valkenet (Onderzoeker); Edwin van Adrichem (Onderzoeker); Jaap Dronkers (Onderzoeker); Jelle Ruurda (Onderzoeker); Cindy Veenhof (Lector)

Background: Preoperative inspiratory muscle training (IMT) is frequently used in patients waiting for major surgery to improve respiratory muscle function and to reduce the risk of postoperative pulmonary complications (PPCs). Currently, the mechanism of action of IMT in reducing PPCs is still unclear. …

2023GezondheidArtikel

A closed-loop ventilation mode that targets the lowest work and force of breathing reduces the transpulmonary driving pressure in patients with moderate-to-severe ARDS

Buiteman-Kruizinga, Laura A.; van Meenen, David M. P.; Bos, Lieuwe D. J.; van der Heiden, Pim L. J.; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.

Introduction The driving pressure (ΔP) has an independent association with outcome in patients with acute respiratory distress syndrome (ARDS). INTELLiVENT-Adaptive Support Ventilation (ASV) is a closed-loop mode of ventilation that targets the lowest work and force of breathing. Aim To compare transpulmonary …

2023AlgemeenArtikel

Broadening the Berlin definition of ARDS to patients receiving high-flow nasal oxygen

van der Ven, Fleur Stefanie L.I.M.; Valk, Christel M.A.; Blok, Siebe; Brouwer, Michelle G.; Go, Dai Ming; Lokhorst, Amanda; Swart, Pien; van Meenen, D. M.; Paulus, F. (Lectoraat Critical Care); Schultz, Marcus J.

Background High-flow nasal oxygen (HFNO) is increasingly used in patients with acute hypoxemic respiratory failure. It is uncertain whether a broadened Berlin definition of acute respiratory distress syndrome (ARDS), in which ARDS can be diagnosed in patients who are not receiving ventilation, results …

2023AlgemeenArtikel

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