Skeletal muscle-related symptoms are common in both acute coronavirus disease (Covid)-19 and post-acute sequelae of Covid-19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, …

Rationale: Patients with cancer of the upper gastrointestinal tract or lung are more likely to present with malnutrition at diagnosis than, for instance, patients with melanoma. Low muscle mass is an indicator of malnutrition and can be determined by computed tomography (CT) analysis of the skeletal …

From October 1980 until May 1981, the Heritage Department of the municipality of Utrecht excavated 173 burials and 40 charnel pits at the former St. Jobsgasthuis. The focus of this thesis is on the skeletal research of the buried individuals in the chapel of the St. Jobsgasthuis. The individuals buried …

This thesis discusses a physical anthropological analysis that was conducted on the skeletal remains found within the chapel of St. Jobs Almshouse. The aim of this analysis was to get an overview of the people buried within the chapel. The main question for this thesis is the following: What insight …

Protein acylation via metabolic acyl-CoA intermediates provides a link between cellular metabolism and protein functionality. A process in which acetyl-CoA and acetylation are fine-tuned is during myogenic differentiation. However, the roles of other protein acylations remain unknown. Protein propionylation …

Background: Cancer cachexia (CC) is a multifactorial syndrome characterised by ongoing skeletal muscle loss that leads to progressive functional impairment driven by reduced food intake and abnormal metabolism. Despite the traditional use of non-volitional weight loss as the primary marker of CC, there …

Background: Society ages, and the incidence of physical limitations and frailty is increasing. For frail older adults, these limitations will lead to more assistance in daily living activities. A significant cause of physical limitation and frailty is sarcopenia, age-related loss of skeletal muscle mass, …

Background: Effective and sustainable interventions are needed to counteract the decline in physical function and sarcopenia in the growing aging population. The aim of this study was to determine the 6 and 12 month effectiveness of blended (e-health + coaching) home-based exercise and a dietary protein …

(1) Background: Recent research showed that subtypes of patients with type 2 diabetes may differ in response to lifestyle interventions based on their organ-specific insulin resistance (IR). (2) Methods: 123 Subjects with type 2 diabetes were randomized into 13-week lifestyle intervention, receiving …