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Docosahexaenoyl Serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23–IL-17 signalling in macrophages

Jean Paul ten Klooster (Lid Lectoraat); Raymond Pieters (Lector); Mieke Polanda; Zheng Wang; Renger Witkamp; Jocelijn Meijerink; Mark Boekschoten

Abstract from the article: "Conjugates of fatty acids and amines, including endocannabinoids, are known to play important roles as endogenous signaling molecules. Among these, the ethanolamine conjugate of the n-3 poly unsaturated long chain fatty acid (PUFA) docosahexaenoic acid (22:6n-3) (DHA) was …

2016-09-26Gezondheid; …Artikel

Unravelling the potential mechanisms behind hospitalization-associated disability in older patients

Reichardt, Lucienne A.; Aarden, Jesse J. (Kenniscentrum Fg); van Seben, Rosanne; van der Schaaf, Marike; Engelbert, Raoul H.H.; Bosch, Jos A.; Buurman, Bianca M.

BACKGROUND: Over 30 % of older patients experience hospitalization-associated disability (HAD) (i.e., loss of independence in Activities of Daily Living (ADLs)) after an acute hospitalization. Despite its high prevalence, the mechanisms that underlie HAD remain elusive. This paper describes the protocol …

2016-03-05AlgemeenArtikel

The efficiency of the NIOO-KNAW proposed decentralized sanitation system in removal of Coliforms and Escherichia coli

Kooten, W. van (Student); Truijen, G.J.P.; Sloots, P.

With increasing world population, more wastewater is produced which all need purification treatment. Removal of pathogenic organisms is important because they can cause problems to human health. This experiment will focus on the removal of human bacterial pathogens. The problem of human bacterial pathogens …

2015-06-25TechniekBachelor

TriPleX-based micro ring resonators for food safety applications

Damen, C.A.J. (Cas) (Lector); Heesink, G.J.T. (Gerard) (Researcher); Heideman, R.G. (Rene) (Lector)

Micro Ring Resonators (MRRs) have become the workhorse in photonics, both for data/telecomas well as bio-chemical sensing applications. In this contribution the use of MRRs as sensors for food-safety applications will be discussed.

2014-11-01AlgemeenConferentiebijdrage

CoPub update

Fleuren, Wilco W M; Verhoeven, Stefan; Frijters, Raoul; Heupers, Bart; Polman, Jan; van Schaik, René; de Vlieg, Jacob; Alkema, Wynand

In this article, we present CoPub 5.0, a publicly available text mining system, which uses Medline abstracts to calculate robust statistics for keyword co-occurrences. CoPub was initially developed for the analysis of microarray data, but we broadened the scope by implementing new technology and new …

2011-05-27AlgemeenArtikel

BioVenn - a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams

Hulsen, Tim; de Vlieg, Jacob; Alkema, Wynand

BACKGROUND: In many genomics projects, numerous lists containing biological identifiers are produced. Often it is useful to see the overlap between different lists, enabling researchers to quickly observe similarities and differences between the data sets they are analyzing. One of the most popular methods …

2008-10-16AlgemeenArtikel

Literature-based compound profiling

Frijters, Raoul; Verhoeven, Stefan; Alkema, Wynand; van Schaik, René; Polman, Jan

Introduction: To reduce continuously increasing costs in drug development, adverse effects of drugs need to be detected as early as possible in the process. In recent years, compound-induced gene expression profiling methodologies have been developed to assess compound toxicity, including Gene Ontology …

2007-11-01AlgemeenArtikel

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