Het NKI is een oncologisch onderzoekscentrum waar wetenschappelijk onderzoek gedaan wordt naar verschillende soorten kanker. Op de afdeling Bio-Farmacologie wordt er voornamelijk onderzoek gedaan naar geneesmiddelen, of een combinatie ervan, die hersentumoren bestrijden. Er worden in vitro en in vivo …

Insulin resistance is common among children with overweight and obesity. However, knowledge about glucose fluctuations in these children is scarce. This study aims to evaluate glycaemic profiles in children with overweight and obesity in free-living conditions, and to examine the association between …

Exercise is one of the external factors associated with impairment of intestinal integrity, possibly leading to increased permeability and altered absorption. Here, we aimed to examine to what extent endurance exercise in the glycogen‐depleted state can affect intestinal permeability toward small molecules …

Plasma gasification has been studied as a new technology which may combine bio-waste treatment and energy generation. Currently, a setup for carrying out gasification experiments has been built up in order to obtain more experimental data for further research. According to previous experimental results, …

BACKGROUND/AIMS: Higher interdialytic weight gain (IDWG) is associated with higher predialysis blood pressure and increased mortality. IDWG is also increasingly being recognized as an indicator of nutritional status. We studied in detail the associations of various patient factors and nutritional parameters …

Postprandial high glucose and insulin responses after starchy food consumption, associated with an increased risk of developing several metabolic diseases, could possibly be improved by altering food structure. We investigated the influence of a compact food structure; different wheat products with a …

Inleiding: Knie-artrose of gonartrose is een aandoening van het kniegewricht en wordt als een van de meest voorkomende oorzaken van invaliditeit genoemd. Startstijfheid in combinatie met pijn is kenmerkend echter, het is niet precies bekend waardoor pijn wordt veroorzaakt. Voor behandeling van gonartrose …

Green tea, particularly epigallocatechin-3-gallate (EGCG), may affect body weight and composition, possibly by enhancing fat oxidation. The aim of this double-blind, randomized placebo-controlled cross-over study was to investigate whether 3-day supplementation with EGCG (282 mg/day) stimulates fat oxidation …

Dietary nitrate (NO3(-)) supplementation has been proposed as an emerging treatment strategy for type 2 diabetes. We hypothesized that ingestion of a single bolus of dietary NO3(-) ingestion improves oral glucose tolerance in patients with type 2 diabetes. Seventeen men with type 2 diabetes (glycated …

Inleiding: Achilles tendinopathie (AT) is een verzamelnaam voor veel voorkomende pijnlijke aandoeningen van de achillespees. Er zijn talloze secundaire conservatieve therapieën ontwikkeld voor AT. Doel van dit literatuuronderzoek is om het effect op pijn van platelet rich plasma (PRP) bij AT in vergelijking …