Implementation of reliable methodologies allowing Reduction, Refinement, and Replacement (3Rs) of animal testing is a process that takes several decades and is still not complete. Reliable methods are essential for regulatory hazard assessment of chemicals where differences in test protocol can influence …

The thoracic and peritoneal cavities are lined by serous membranes and are home of the serosal immune system. This immune system fuses innate and adaptive immunity, to maintain local homeostasis and repair local tissue damage, and to cooperate closely with the mucosal immune system. Innate lymphoid cells …

Hoe bouwen we aan een samenleving waarin iedereen kan meedoen, tot zijn recht komt en zich veilig voelt? Hier doen de lectoraten praktijkgericht onderzoek van het Kenniscentrum Sociale In-novatie van Hogeschool Utrecht onderzoek naar, met en voor (aankomend) sociale professionals in het brede sociaal …

BACKGROUND: We recently developed a model of stratified exercise therapy, consisting of (i) a stratification algorithm allocating patients with knee osteoarthritis (OA) into one of the three subgroups ('high muscle strength subgroup' representing a post-traumatic phenotype, 'low muscle strength subgroup' …

Introduction: Midwifery education that strengthens self-efficacy can support student midwives in their role as advocates for a physiological approach to childbirth. Methods: To assess the effect of an educational intervention on self-efficacy, a pre- and post-intervention survey was administered to …

During the first half of 2020, the outbreak of the COVID-19 virus had a huge global impact. The physical health of many was (often severely) threatened and affected, resulting in numerous deaths. Furthermore, all aspects of human coexistence came under pressure, such as economic activities and material …

Background: The maternity care system in the Netherlands is well known for its support of community-based midwifery. However, regular midwifery practices typically do not offer caseload midwifery care – one-to-one continuity of care throughout pregnancy and birth. Because we know very little about the …

Introduction: Strenuous physical stress induces a range of physiological responses, the extent depending, among others, on the nature and severity of the exercise, a person’s training level and overall physical resilience. This principle can also be used in an experimental set-up by measuring time-dependent …

Hoe doen sociaal werkers hun werk in coronatijden? Wat betekent het beeldbellen voor de kern van hun beroep: contact onderhouden? Het wordt moeilijker voor ze om onder deze omstandigheden hun professionele verantwoordelijkheid waar te maken, zo blijkt uit een peiling van het Kenniscentrum Sociale Innovatie …

Background: Research on maternity care often focuses on factors that prevent good communication and collaboration and rarely includes important stakeholders – parents – as co-researchers. To understand how professionals and parents in Dutch maternity care accomplish constructive communication and collaboration, …