HBO Kennisbank

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Zocht je misschien: video, vital?

Alternatives to animals

Marc Teunis (Lid Lectoraat)

International Innovation is the leading global dissemination resource for the wider scientific, technology and research communities, dedicated to disseminating the latest science, research and technological innovations on a global level. More information and a complimentary subscription offer to the …

2013AlgemeenArtikel

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Smeets, Ruben L; Fleuren, Wilco W M; He, Xuehui; Vink, Paul M; Wijnands, Frank; Gorecka, Monika; Klop, Henri; Bauerschmidt, Sussane; Garritsen, Anja; Koenen, Hans J P M; Joosten, Irma; Boots, Annemieke M H; Alkema, Wynand

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed …

2012-03-14AlgemeenArtikel

Literature mining for the discovery of hidden connections between drugs, genes and diseases

Frijters, Raoul; van Vugt, Marianne; Smeets, Ruben; van Schaik, René; de Vlieg, Jacob; Alkema, Wynand

The scientific literature represents a rich source for retrieval of knowledge on associations between biomedical concepts such as genes, diseases and cellular processes. A commonly used method to establish relationships between biomedical concepts from literature is co-occurrence. Apart from its use …

2010-09-23AlgemeenArtikel

Polyploidization of Lilium and Tulipa

Zhang, S. (Student); Campbell, T.

There are two aims of this thesis; one is selecting 2n pollen producers from F1 hybrids of T. gesneriana x T. fosteriana tulip hybrids crossing experiment. Furthermore, to test one year old tulip seedlings for ploidy levels of the F1 progenies in order to determine the result of the function of the 2n …

2010Natuur & LandbouwBachelor

'Motivatie en interventies bij gedrags-veranderings-bereidheid'

Tom de Jonge (Student); M Mataheru (Begeleider)

In deze casestudy leest u hoe de dubbele diagnose (dd) cliënt te werk gaat in zijn of haar behandeling. Ik richt mij op de klinisch dynamische behandelgroep. De dd cliënten uit deze groep hebben voornamelijk een hoofddiagnose op de as II (persoonlijkheidsstoornissen) in combinatie met een middelen-afhankelijkheids-problematiek. …

2010GezondheidBachelor

Target validation in silico

Alkema, Wynand; Rullmann, Ton; van Elsas, Andrea

Genomics has multiplied the number of targets for new therapeutic interventions, but this has not yet lead to a marked increase of pharma pipeline outputs. The complexity of protein function in higher order biological systems is often underestimated. Translation from in vitro and in vivo results to the …

2006-09-16AlgemeenArtikel

Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells

Roelofs, Anke J.; Hulley, Philippa A.; van der Heij-Meijer, Annemieke; Ebetino, Frank H.; Russell, R. Graham G.; Shipman, Claire M.

Bisphosphonates (BPs) are widely used in the treatment of osteolytic bone disease associated with multiple myeloma, and have been demonstrated to exert antitumor effects both in vitro and in vivo. However, the precise molecular mechanisms involved in the direct antitumor effects of BPs in vitro are not …

2006-04-17AlgemeenArtikel

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