Abstract Frailty syndrome (FS) is an independent predictor of mortality in cardiovascular disease and is found in 15-74% of patients with heart failure (HF). The syndrome has a complex, multidimensional aetiology and contributes to adverse outcomes. Proper FS diagnosis and treatment determine prognosis …

Presentation at the RCE, Amersfoort during the WTA-international (Wissenschaftlich-Technische Arbeitsgemeinschaft für Bauwerkserhaltung und Denkmalpflege) meeting about earthquakes and building.

Fraeylemaborg is a noble house in an earthquake-stricken area of the Netherlands due to the induced seismicity events in the region. The structure is located in the middle of the town of Slochteren which gave its name to the largest gas field in the world upon its discovery in 1959. The gas extraction …

Background: Increasing attention to palliative care for the general population has led to the development of various evidence-based or consensus-based tools and interventions. However, specific tools and interventions are needed for people with severe mental illness (SMI) who have a life-threatening …

In children developmental disorders expresses themselves by a variable presentation of symptoms and frequent manifestation of comorbidity of a complex nature. In addition to the classification of a disorder, individualising diagnostics is a means to realize assessment and treatment that are fine-tuned …

Purpose: Measurement of muscle mass is paramount in the screening and diagnosis of sarcopenia. Besides muscle quantity however, also quality assessment is important. Ultrasonography (US) has the advantage over dual-energy X-ray absorptiometry (DEXA) and bio-impedance analysis (BIA) to give both quantitative …

Rationale: Diagnosis of sarcopenia in older adults is essential for early treatment in clinical practice. Bio-electrical impedance analysis (BIA) may be a valid means to assess appendicular lean mass (ALM) in older adults, but limited evidence is available. Therefore, we aim to evaluate the validity …

Naar aanleiding van het tekortschietende geïntegreerde behandelaanbod voor dubbel diagnose patiënten en de groeiende vraag naar kosteneffectieve interventies binnen de Nederlandse GGZ is onderzocht wat het behandeleffect is op de psychische gezondheidstoestand van dubbel diagnose patiënten na het volgen …

Objective Despite the increasing recognition in clinical practice of body image problems in other than appearance related mental disorders, the question remains how aspects of body image are affected in different disorders. The aim of this study was to measure body image in patients with a variety of …

Accurate assessment of TP53 gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li–Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and therapy. Genomic data from more than 20,000 cancer genomes provide a wealth of information …