Background The ROS1 G2032R mutation is the most common on-target resistance mutation in crizotinib treated ROS1-positive lung cancer patients. The aim of our study was to investigate resistance mechanisms in SCL34A2-ROS1G2032R positive Ba/F3 cells against second line treatment with lorlatinib. Methods …

Aggregation into groups may affect performance of individuals through the balance and strength of facilitative versus competitive interactions. We studied in situ how seasonal variation in abiotic environment affects this balance for blue mussels, a semi-sessile species. We hypothesize that seasonal …

Electric vehicles have penetrated the Dutch market, which increases the potential for decreased local emissions, the use and storage of sustainable energy, and the roll-out and use of electric car-sharing business models. This development also raises new potential issues such as increased electricity …

PURPOSE: Describe prevalence and severity of fatigue in children and adolescents with burns during six months after hospital discharge, identify potential explanatory variables, and examine the relationship with exercise capacity. MATERIALS AND METHODS: Fatigue was assessed using the Pediatric-Quality-of-Life-Inventory-Multidimensional-Fatigue-Scale …

Over the years, infant formula has become an important source of nutrition for infants, the demand for infant formula is constantly growing (Scotti, 2023). Over the last couple of decades, breastfeeding rates among mothers in the Netherlands have decreased from 74-81% to 69% (Engelse & Van Dummelen, …

Pollinator biodiversity has decreased in the past decades, but urban areas have increasingly been found to serve as a refuge when compared to the surrounding intensively managed farmland. This offers an opportunity for urban pollinator conservation to play a role in the conservation of pollinators. But …

Objective To determine the effect of a multidisciplinary lifestyle program in patients with RA with low–moderate disease activity. Methods In the ‘Plants for Joints’ (PFJ) parallel-arm, assessor-blind randomized controlled trial, patients with RA and 28-joint DAS (DAS28) ≥2.6 and ≤5.1 were randomized …

Mate value is an important concept in mate choice research although its operationalization and understanding are limited. Here, we reviewed and evaluated previously established conceptual and methodological approaches measuring mate value and presented original research using individual differences in …

Support for relatives is highly important in the intensive care unit (ICU). During the first COVID-19 wave support for relatives had to be changed considerably. The alternative support could have decreased the quality and sense of support. We aimed to evaluate how support for relatives in Dutch ICUs …

Aims: This systematic review and meta-analysis evaluates the additional effect of exercise to hypocaloric diet on body weight, body composition, glycaemic control and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes.  Methods: Embase, Medline, Web of Science and Cochrane …