It is estimated that over 30,000 lesions in the DNA are generated per cell per day. In S-phase, lesions in the DNA can stall replication, which can lead to secondary lesions such as DNA double- strand breaks. The DNA damage tolerance (DDT) network enables replication to be continued in the presence of …

BACKGROUND AND AIMS: We aimed to investigate the test-retest reliability and validity of ultrasound for two commonly used types of transducer, using different methods for the estimation of muscle size and echo intensity (EI). METHODS: Fourteen healthy adults were included in this study. Ultrasound images …

The four previous articles in this series addressed the myths and facts surrounding lipoedema. We have shown that there is no scientific evidence at all for the key statements made about lipoedema-which are published time and time again. The main result of this misunderstanding of lipoedema is a therapeutic …

INTRODUCTION: This study investigated the effect of operative claw toe correction with release of the metatarsophalangeal (MTP) joint, repositioning of the plantar fat pad and resection of the proximal interphalangeal joint on foot kinematics, plantar pressure distribution and Foot Function Index (FFI). …

INLEIDING: Ruim 17.000 mensen in Nederland hebben nierfalen. Door toename van het aantal mensen met diabetes type 2 in de wereld, groeit het aantal mensen met nierfalen snel. Nierfunctieverlies kan leiden tot vermindering van de eetlust, dit veroorzaakt ondervoeding. Ondervoeding heeft invloed op de …

Introduction: There are two surgical approaches to reconstruct a pressure ulcer (PU): one-stage reconstruction or two-stage reconstruction. One stage reconstruction consists of surgical debridement and flap reconstruction during one operation. Two-stage surgery consist of a surgical debridement and a …

Disability in children diagnosed with hypermobility syndrome (HMS) and Ehlers-Danlos (hypermobility type: EDS-HT) can vary from mild to very severe. This disability can be of temporary nature but for some may persist and become chronic, eventually leading to disablement. Historically it is believed that …

Scar formation is an important adverse consequence of burns. How patients appraise their scar quality is often studied shortly after sustaining the injury, but information in the long-term is scarce. Our aim was, therefore, to evaluate long-term patient-reported quality of burn scars. Adults with a burn …

Emotions of people should be challenged instead of being pushed away. Can architecture as part of the urban tissue reach out to a broader audience and be supportive in terms of mental functioning? A two-level visitor center, open and public on the ground floor, secluded on the first floor, offers chances …

Abstract Background: We studied the relationship between trismus (maximum interincisor opening [MIO] ≤35 mm) and the dose to the ipsilateral masseter muscle (iMM) and ipsilateral medial pterygoid muscle (iMPM). Methods: Pretreatment and post-treatment measurement of MIO at 13 weeks revealed 17% of …