HBO Kennisbank

263 Resultaten

Sorteer op:

Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19

Daenen, Katrijn; Huijben, Jilske A; Boyd, Anders; Bos, Lieuwe D J; Stoof, Sara C M; van Willigen, Hugo; Gommers, Diederik A M P J; Moeniralam, Hazra S; den Uil, Corstiaan A; Juffermans, Nicole P; Kant, Merijn; Valkenburg, Abraham J; Pillay, Janesh; van Meenen, David M P; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J; Dalm, Virgil A S H; van Gorp, Eric C M; Schinkel, Janke; Endeman, Henrik

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose …

2023-01AlgemeenArtikel

Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.

B. den Hollander; A.R.J. Veenvliet; Marieke Lindenschot; P. van Essen; G. Peters; A. Santos-Gómez; M. Olivella; X. Altafaj; M.M. Brands; B.A.W. Jacobs; C.D. van Karnebeek

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

2023AlgemeenArtikel

Physiotherapy with integrated virtual reality for patients with complex chronic low back pain: protocol for a pragmatic cluster randomized controlled trial (VARIETY study).

S. Slatman; R. Ostelo; H. van Goor; Bart Staal; J. Knoop

BACKGROUND: Chronic low back pain (CLBP) is the most common chronic pain condition worldwide. Currently, primary care physiotherapy is one of the main treatment options, but effects of this treatment are small. Virtual Reality (VR) could be an adjunct to physiotherapy care, due to its multimodal features. …

2023AlgemeenArtikel

The impact of high versus standard enteral protein provision on functional recovery following intensive care admission (PRECISE trial)

van Gassel, Rob J. J.; Bels, Julia L. M.; Tartaglia, Katrien; van Bussel, Bas C. T.; van Kuijk, Sander M. J.; Deane, Adam M.; Puthucheary, Zudin; Weijs, Peter J. M. (Lectoraat Voeding En Beweging); Vloet, Lilian; Beishuizen, Bert; De Bie Dekker, Ashley; Fraipont, Vincent; Lamote, Stoffel; Ledoux, Didier; Scheeren, Clarissa; De Waele, Elisabeth; van Zanten, Arthur R. H.; Mesotten, Dieter; van de Poll, Marcel C. G.

Background Critically ill patients are subject to severe skeletal muscle wasting during intensive care unit (ICU) stay, resulting in impaired short- and long-term functional outcomes and health-related quality of life. Increased protein provision may improve functional outcomes in ICU patients by attenuating …

2023AlgemeenArtikel

Effect of lung ultrasound-guided fluid deresuscitation on duration of ventilation in intensive care unit patients (CONFIDENCE)

Blok, Siebe G.; Mousa, Amne; Brouwer, Michelle G.; de Grooth, Harm-Jan; Neto, Ary Serpa; Blans, Michiel J.; den Boer, Sylvia; Dormans, Tom; Endeman, Henrik; Roeleveld, Timo; Scholten, Harm; van Slobbe-Bijlsma, Eline R.; Scholten, Erik; Touw, Hugo; van der Ven, Fleur Stefanie L. I. M.; Wils, Evert-Jan; van Westerloo, David J.; Heunks, Leo M. A.; Schultz, Marcus J.; Paulus, Frederique (Lectoraat Critical Care); Tuinman, Pieter R.

Background Fluid therapy is a common intervention in critically ill patients. It is increasingly recognised that deresuscitation is an essential part of fluid therapy and delayed deresuscitation is associated with longer invasive ventilation and length of intensive care unit (ICU) stay. However, optimal …

2023AlgemeenArtikel

Activating Relatives to Get Involved in Care After Surgery: Protocol for a Prospective Cohort Study

Musters, Selma C W; Kreca, Sani; van Dieren, Susan; van der Wal-Huisman, Hanneke; Romijn, Johannes A; Chaboyer, Wendy; Nieveen van Dijkum, Els J M; Eskes, Anne M (Lectoraat Patiënt- En Familieparticipatie In De Klinische Zorg)

Background: Postoperative complications and readmissions to hospital are factors known to negatively influence the short- and long-term quality of life of patients with gastrointestinal cancer. Active family involvement in activities, such as fundamental care activities, has the potential to improve …

2023AlgemeenArtikel

Effect and process evaluation of a preschool-based intervention to promote an early childhood education and care teacher-parent partnership about healthy behaviours in children: Study protocol for the cluster randomised controlled trial CO-HEALTHY

Toussaint, Nicole (Urban Vitality); Streppel, Martinette T. (Lectoraat Voeding En Beweging); Mul, Sandra (Lectoraat Voeding En Beweging); Gündüz, Meryem (Lectoraat Voeding En Beweging); van Verseveld, Marloes D.A.; Janssen, Mirka (Lectoraat Bewegen In En Om School); Weijs, Peter J. M. (Lectoraat Voeding En Beweging); Fukkink, Ruben G. (Kenniscentrum Onderwijs En Opvoeding)

Background Early Childhood Education and Care (ECEC) teachers at urban preschools are potential key figures to promote healthy behaviours in disadvantaged young children and to engage parents in lifestyle-related topics. An ECEC teacher-parent partnership regarding healthy behaviours may support parents …

2023AlgemeenArtikel

Excitation Transfer Between Sexual Arousal and Other Emotions: Study Protocol

Eveline Schippers (Onderzoeker); Wineke Smid (Onderzoeker); Larissa Hoogsteder (Onderzoeker); Vivienne de Vogel (Onderzoeker)

Background: Sexual deviance is regarded as an important risk factor for sexual offending. However, little is known about the development of deviant sexual interests. The transfer of arousal between emotions, i.e., excitation transfer, could attribute sexual salience to stimuli that would otherwise not …

2023Mens & MaatschappijArtikel

Salivary concentrations of secretory leukocyte protease inhibitor and matrix metallopeptidase-9 following a single bout of exercise are associated with intensity and hydration status

Karen Knipping (Onderzoeker); Shirley Kartaram (Onderzoeker); Marc Teunis (Onderzoeker); Nicolaas Zuithoff (Onderzoeker); Nicole Buurman (Onderzoeker); Laura M'Rabet (Onderzoeker); Klaske van Norren (Onderzoeker); Renger Witkamp (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker)

Aim: To investigate the effects of exercise on salivary concentrations of inflammatory markers by analyzing a panel of 25 inflammatory markers in subjects who had participated in bicycle ergometer tests varying in workload and hydration status. Methods: Fifteen healthy young men (20-35 years) had performed …

2023GezondheidArtikel

Interventions to reduce interpersonal stigma towards patients with a mental dysregulation for ambulance and emergency department healthcare professionals: review protocol for an integrative review

Geurt van de Glind (Onderzoeker); Niek Galenkamp (Onderzoeker); Nienke Bleijenberg (Lector); Lisette Schoonhoven (Onderzoeker); Floortje Scheepers (Onderzoeker); Julia Crilly (Onderzoeker); Mark van Veen (Onderzoeker); Wietske Blom-Ham (Onderzoeker)

Introduction: Worldwide, there is an increase in the extent and severity of mental illness. Exacerbation of somatic complaints in this group of people can result in recurring ambulance and emergency department care. The care of patients with a mental dysregulation (ie, experiencing a mental health problem …

2023GezondheidArtikel

1...5 6 7...

Over HBO Kennisbank