Background Routine outpatient care of patients with coronary artery disease (CAD) lacks a simple measure of physical fitness and risk of mortality. Heart rate recovery (HRR) is noninvasive and easily obtainable in outpatient settings. Prior studies have suggested that delayed postexercise HRR in the …

I was somewhat surprized with the fog in Groningen upon my arrival. This is not the fog that covers the beautiful landscapes of the northern Netherlands in the evening and in the early morning. No… It is the fog that obscures the real aspects of the earthquake problem in the region and is crystallised …

Currently, published risk analyses for drones refer mainly to commercial systems, use data from civil aviation, and are based on probabilistic approaches without suggesting an inclusive list of hazards and respective requirements. Within this context, this paper presents: (1) a set of safety requirements …

From the article: "To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening assays need to be translational to humans, have …

from the repository of Utrecht University: "OBJECTIVES: Antipsychotic drugs are frequently prescribed to elderly patients, but they are associated with serious adverse effects. The objective of the current study was to investigate the association between use of antipsychotics by elderly women and the …

Collapses of school or dormitory buildings experienced in recent earthquakes raise the issue of safety as a major challenge for decision makers. A school building is ‘just another structure’ technically speaking, however, the consequences of a collapse in an earthquake could lead to social reactions …

Background: Pancreatic cancer has a dire prognosis and is associated with a high mortality. Palliative patients have special needs and often seek help in integrative oncological concepts (IO) that combine conventional and complementary therapies. Nevertheless there are few recommendations regarding IO …

Risk matrices have been widely used in the industry under the notion that risk is a product of likelihood by severity of the hazard or safety case under consideration. When reliable raw data are not available to feed mathematical models, experts are asked to state their estimations. This paper presents …

ABSTRACT It is unknown whether heterogeneity in effects of self-management interventions in patients with chronic obstructive pulmonary disease (COPD) can be explained by differences in programme characteristics. This study aimed to identify which characteristics of COPD self-management interventions are …

Objectives To assess the independent association between health-related quality of life (HRQOL) at admission and mortality, functional decline, and institutionalization 3 and 12 months after admission in acutely hospitalized older adults. Design Post hoc analysis of data from prospective cohort study, …