INTRODUCTION: Physical Activity (PA) is essential for enhancing the physical function of pre-frail and frail older adults. However, among this group, PA-levels vary significantly. Identifying the factors contributing to these differences could support tailored PA interventions. This study aims to examine …

Nicotine is a well-known and highly addictive substance with complex effects on cognition, anxiety, and neurophysiology. Despite its short-term anxiolytic effects, this drug often exacerbates anxiety symptoms. It disrupts emotional regulation through its impact on the central nucleus of the amygdala …

Introduction: To determine if athletes with coordination impairment (CI) can continue playing wheelchair rugby (WR), while an evidence-based classification system, including impairment tests for CI is not yet available. This is a defensible practise if they show similar activity limitations as athletes …

Stargazing Live! aims to capture the imagination of learners with a combination of live and interactive planetarium lessons, real astronomical data, and lessons built around interactive knowledge representations. The lessons were created using a co-creation model and tackle concepts in the pre-university …

Background: To avoid overexertion in critically ill patients, information on the physical demand, i.e., metabolic load, of daily care and active exercises is warranted. Objective: The objective of this study was toassess the metabolic load during morning care activities and active bed exercises in mechanically …

Objective. After laryngectomy, the breathing resistance of heat and moisture exchangers may limit exercise capacity. Breathing gas analysis during cardiopulmonary exercise testing is not possible using regular masks. This study tested the feasibility of cardiopulmonary exercise testing with a heat and …

Post-earthquake structural damage shows that out-of-plane wall collapse is one of the most prevalent failure mechanisms in unreinforced masonry (URM) buildings. This issue is particularly critical in Groningen, a province located in the northern part of the Netherlands, where low-intensity ground shaking …

Background: Recent world population predictions show that the world population aged >=65 years will increase from 10% in 2022 to 16% in 2050. Population aging is accompanied by an increase in people with disability. It is important to pay special attention to people with disability, as these people …

The closing of schools and sports clubs during theCOVID-19 lockdown raised questions about thepossible impact on children’s motor skilldevelopment. Therefore we compared motorcompetence development over a one-year periodamong four different cohorts of primary schoolchildren. A total of 992 children from …

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …