Abstract: Existing frailty models have enhanced research and practice; however, none of the models accounts for the perspective of older adults upon defining and operationalizing frailty. We aim to propose a mixed conceptual model that builds on the integral model while accounting for older adults’ perceptions …

This dissertation concerns the adaptive ability by which workers meet new expertise needs throughout their careers. We aimed to increase our understanding of this adaptive ability through a series of four studies building upon the concept of flexpertise (Van der Heijden, 1998, …

Metaverse, a burgeoning technological trend that combines virtual and augmented reality, provides users with a fully digital environment where they can assume a virtual identity through a digital avatar and interact with others as they were in the real world. Its applications span diverse domains such …

This study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the institutional medical ethic committee (number CWO -1911) and funded by Altrecht Mental Health Care. All participants of this study signed informed consent. The participants of this study did …

This doctoral dissertation aims to address the challenges faced by physical education (PE) teachers in building an inclusive learning environment that promotes a physically active lifestyle among secondary school students. Although existing research offers useful empirical insights into addressing this …

Patients with extensive and complex wounds due to Necrotizing Soft-Tissue Infections (NSTI) may be referred to a burn center. This study describes the characteristics, outcomes, as well as diagnostic challenges of these patients. Patients admitted to three hospitals with a burn center for the treatment …

Background The ROS1 G2032R mutation is the most common on-target resistance mutation in crizotinib treated ROS1-positive lung cancer patients. The aim of our study was to investigate resistance mechanisms in SCL34A2-ROS1G2032R positive Ba/F3 cells against second line treatment with lorlatinib. Methods …

Inaugural lecture, delivered upon public acceptance of the endowed professorship in Professionalisation of Nursing and Care in Elderly Care by Prof. Dr. Robbert J.J. Gobbens at Tilburg University on 29 September 2023.

Background Refrigerated containers or 'reefers' are essential for transporting fresh fruit and vegetables in transnational supply chains. By refrigeration, they ensure that food quality is better preserved and food losses are reduced. Countries that produce fresh produce also unlock new markets for export …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. It is the number one cause of death in the Intensive Care Unit (ICU), accounting for 6 million casualties every year. Unfortunately, all clinical trials in the last decade failed due to the highly complex …