Informal caregivers of frail elderly people often perform a substantial number of care tasks over a prolonged period of time [1]. By definition, informal care is nonprofessional and unpaid and is provided by family members, partners or close friends [2]. Frail elderly people suffer from age-related problems …

Background: Post-term pregnancy, a pregnancy exceeding 294 days or 42 completed weeks, is associated with increased perinatal morbidity and mortality and is considered a high-risk condition which requires specialist surveillance and induction of labour. However, there is uncertainty on the policy …

Probiotic bacteria harbor effector molecules that confer health benefits, but also adaptation factors that enable them to persist in the gastrointestinal tract of the consumer. To study these adaptation factors, an antibiotic-resistant derivative of the probiotic model organism Lactobacillus plantarum …

There is growing realisation amongst local communities that the organizations and societies within which they live and work need to become more sustainable in order to secure their social, environmental and economic futures (Coyle 2011, Müller et al. 2011). The underlying motivations vary but are often …

The Turkish Republic has a great history with major defeats and victories in its past. Since the fourteenth century Turkey was part of the Ottoman Empire. During the following centuries, the Empire expanded and covered areas which are nowadays known as Europe, Asia and North Africa. The twentieth century …

Er is wereldwijd een groeiende groep milieuvluchtelingen. Voor deze mensen, die vluchten als gevolg van bijvoorbeeld een tsunami, dijkdoorbraak, hoge concentraties vrijkomende giftige stoffen bij een industrieel ongeval, verwoestijning, uitputting van de bodem of langdurige regenval, bestaat nog geen …

BACKGROUND: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression …

Several models have been developed to predict prolonged stay in the intensive care unit (ICU) after cardiac surgery. However, no extensive quantitative validation of these models has yet been conducted. This study sought to identify and validate existing prediction models for prolonged ICU length of …

The studies reported on in this thesis addressed the development of sucking patterns in preterm newborns. Preterm infants often have problems learning to suckle at the breast or to drink from a bottle. It is unclear whether this is due to their preterm birth or whether it is the consequence of neurological …

Thermal injury destroys the physical skin barrier that normally prevents invasion of microorganisms. This and concomitant depression of local and systemic host cellular and humoral immune responses are important factors that contribute to colonization and infection of the burn wound. One of the most …