Wilms tumour suppressor gene (WT1) is essential for normal development of a kidney, it was also discovered as a major controller of mesenchymal-epithelial balance in general development of organs. In this project we use Wt1 and its role in the mesenchymal-epithelial balance to study the mechanism of …

Presentatie bij Deutsches Forschungszentrum für Künstliche Intelligenz over aardbevingen en onderzoek hierover

Fraeylemaborg is a noble house in an earthquake-stricken area of the Netherlands due to the induced seismicity events in the region. The structure is located in the middle of the town of Slochteren which gave its name to the largest gas field in the world upon its discovery in 1959. The gas extraction …

Chronic low back pain (CLBP) has major public health implications, and underlying mechanisms are still unclear. Sensorimotor incongruence (SMI)—an ongoing mismatch between top-down motor output and predicted sensory feedback—may play a role in the course of chronic nonspecific low back pain. The hypothesis …

Valuation of heritage buildings is usually performed by architectural-historical experts, who use a typology of heritage values based on conservation philosophy. Increasingly, social and spirituality values are included in heritage assessment frameworks. What happens to valuation systems when external …

Background A key factor in successfully preventing falls, is early identification of elderly with a high risk of falling. However, currently there is no easy-to-use pre-screening tool available; current tools are either not discriminative, time-consuming and/or costly. This pilot investigates the feasibility …

Due to the many potential applications of Big Data, the expectations are high. However, there are some fundamental objections on the straightforward use of Big Data outcomes. In this paper, we take a philosophical view on the Big Data approach and discuss these objections. Formally, Big Data induces …

Purpose:To determine which health care provider and what timing is considered most suitable to discuss sexual and relationalchanges after prostate cancer treatment according to the point of view of men and their partners. Methods A cross-sectional survey was conducted among men diagnosed with prostate …

For hypertensive women in CHIPS (Control of Hypertension in Pregnancy Study), we assessed whether the maternal benefits of tight control could be achieved, while minimizing any potentially negative effect on fetal growth, by delaying initiation of antihypertensive therapy until later in pregnancy. For …