Generalized joint hypermobility (GJH) is highly prevalent among patients diagnosed with chronic pain. When GJH is accompanied by pain in ≥4 joints over a period ≥3 months in the absence of other conditions that cause chronic pain, the hypermobility syndrome (HMS) may be diagnosed. In addition, GJH is …

Background: The awareness is growing that central sensitization is of prime importance for the assessment and management of chronic pain, but its classification is challenging clinically since no gold standard method of assessment exists. Objectives: Designing the first set of classification criteria …

BACKGROUND: Generalized Joint Hypermobility (GJH) has been found to be associated with musculoskeletal complaints and disability. For others GJH is seen as a prerequisite in order to excel in certain sports like dance. However, it remains unclear what the role is of GJH in human performance. Therefore, …

Obesitas is een steeds vaker voorkomende aandoening in West-Europa, Noord-Amerika en andere welvarende delen van de wereld. Uit recent onderzoek van het RIVM is gebleken dat van de gehele volwassen populatie in Nederland in 2012, zo’n 40% overgewicht heeft en 12% obesitas. Bij obesitas vindt een ophoping …

When treating cancer by radiation therapy it is always the goal to irradiate the tumour as much as possible and to spare the healthy tissue around it. For this a new type of radiation therapy called Volumetric Modulated ARC Therapy (VMAT) has been developed. During VMAT treatment the radiation machine …

BACKGROUND: Hyperbaric oxygen therapy (HBOT) is used as a treatment for acute wounds (such as those arising from surgery and trauma). However, the effects of HBOT on wound healing are unclear. OBJECTIVES: To determine the effects of HBOT on the healing of acute surgical and traumatic wounds. SEARCH METHODS: …

Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

Cancer is a worldwidehuman health problem.This is why much effortis put in finding solutions and treatments for this disease. One of the emerging adjuvant cancer treatments, hyperthermia, is applied by heating the tumourtissue, and is shown to increase the effects of radio and/ or chemotherapy. Because …

The Rhine-Waal Valley needs an urban tissue with excellent liveability standards. By restoring the harmony between occupation patterns, landscape structures and natural processes, a new balance will flourish between man and nature. A careful alignment based upon the specific characteristics of the “water …

Achtergrond: Vooralsnog is er geen behandeling bekend welke genezing van artrose kan geven. Vanuit de literatuur zijn er aanwijzingen dat het zinvol is de biomechanische toestand van het artrotische gewricht te herstellen. Met gewrichtsdistractie bij knie- en enkelartrose wordt gepoogd, door middel van …